Function and therapeutic value of astrocytes in neurological diseases
Astrocytes are abundant glial cells in the central nervous system (CNS) that perform diverse
functions in health and disease. Astrocyte dysfunction is found in numerous diseases …
functions in health and disease. Astrocyte dysfunction is found in numerous diseases …
Targeting epigenetic and posttranslational modifications regulating ferroptosis for the treatment of diseases
Y Wang, J Hu, S Wu, JS Fleishman, Y Li, Y Xu… - Signal transduction and …, 2023 - nature.com
Ferroptosis, a unique modality of cell death with mechanistic and morphological differences
from other cell death modes, plays a pivotal role in regulating tumorigenesis and offers a …
from other cell death modes, plays a pivotal role in regulating tumorigenesis and offers a …
Potential drug targets for multiple sclerosis identified through Mendelian randomization analysis
J Lin, J Zhou, Y Xu - Brain, 2023 - academic.oup.com
Multiple sclerosis is a complex autoimmune disease, and several therapies for multiple
sclerosis have been developed and widely used. However, existing medications for multiple …
sclerosis have been developed and widely used. However, existing medications for multiple …
Bruton tyrosine kinase inhibitors for multiple sclerosis
Current therapies for multiple sclerosis (MS) reduce both relapses and relapse-associated
worsening of disability, which is assumed to be mainly associated with transient infiltration of …
worsening of disability, which is assumed to be mainly associated with transient infiltration of …
Oligodendrocyte death and myelin loss in the cuprizone model: an updated overview of the intrinsic and extrinsic causes of cuprizone demyelination
Background The dietary consumption of cuprizone–a copper chelator–has long been known
to induce demyelination of specific brain structures and is widely used as model of multiple …
to induce demyelination of specific brain structures and is widely used as model of multiple …
Advances in neurodegenerative diseases
J Van Schependom, M D'haeseleer - Journal of clinical medicine, 2023 - mdpi.com
Neurological disorders are the leading cause of physical and cognitive disability across the
globe, currently affecting approximately 15% of the worldwide population [1]. Absolute …
globe, currently affecting approximately 15% of the worldwide population [1]. Absolute …
[HTML][HTML] CNS remyelination and inflammation: From basic mechanisms to therapeutic opportunities
Remyelination, the myelin regenerative response that follows demyelination, restores
saltatory conduction and function and sustains axon health. Its declining efficiency with …
saltatory conduction and function and sustains axon health. Its declining efficiency with …
The role of glial cells in multiple sclerosis disease progression
Despite the development of highly effective treatments for relapsing–remitting multiple
sclerosis (MS), limited progress has been made in addressing primary progressive or …
sclerosis (MS), limited progress has been made in addressing primary progressive or …
STING orchestrates the neuronal inflammatory stress response in multiple sclerosis
Inflammation-induced neurodegeneration is a defining feature of multiple sclerosis (MS), yet
the underlying mechanisms remain unclear. By dissecting the neuronal inflammatory stress …
the underlying mechanisms remain unclear. By dissecting the neuronal inflammatory stress …
Central nervous system macrophages in progressive multiple sclerosis: relationship to neurodegeneration and therapeutics
E Kamma, W Lasisi, C Libner, HS Ng… - Journal of …, 2022 - Springer
There are over 15 disease-modifying drugs that have been approved over the last 20 years
for the treatment of relapsing–remitting multiple sclerosis (MS), but there are limited …
for the treatment of relapsing–remitting multiple sclerosis (MS), but there are limited …