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Drug repurposing for cancer therapy
Cancer, a complex and multifactorial disease, presents a significant challenge to global
health. Despite significant advances in surgical, radiotherapeutic and immunological …
health. Despite significant advances in surgical, radiotherapeutic and immunological …
Network pharmacology approach for medicinal plants: review and assessment
Natural products have played a critical role in medicine due to their ability to bind and
modulate cellular targets involved in disease. Medicinal plants hold a variety of bioactive …
modulate cellular targets involved in disease. Medicinal plants hold a variety of bioactive …
Spatiotemporal immune landscape of colorectal cancer liver metastasis at single-cell level
Liver metastasis, the leading cause of colorectal cancer mortality, exhibits a highly
heterogeneous and suppressive immune microenvironment. Here, we sequenced 97 …
heterogeneous and suppressive immune microenvironment. Here, we sequenced 97 …
Toward better drug discovery with knowledge graph
Drug discovery is the process of new drug identification. This process is driven by the
increasing data from existing chemical libraries and data banks. The knowledge graph is …
increasing data from existing chemical libraries and data banks. The knowledge graph is …
Ensembl 2019
Abstract The Ensembl project (https://www. ensembl. org) makes key genomic data sets
available to the entire scientific community without restrictions. Ensembl seeks to be a …
available to the entire scientific community without restrictions. Ensembl seeks to be a …
Genetic meta-analysis of diagnosed Alzheimer's disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing
Risk for late-onset Alzheimer's disease (LOAD), the most prevalent dementia, is partially
driven by genetics. To identify LOAD risk loci, we performed a large genome-wide …
driven by genetics. To identify LOAD risk loci, we performed a large genome-wide …
Biobank-driven genomic discovery yields new insight into atrial fibrillation biology
To identify genetic variation underlying atrial fibrillation, the most common cardiac
arrhythmia, we performed a genome-wide association study of> 1,000,000 people, including …
arrhythmia, we performed a genome-wide association study of> 1,000,000 people, including …
Genome-wide association analyses of risk tolerance and risky behaviors in over 1 million individuals identify hundreds of loci and shared genetic influences
Humans vary substantially in their willingness to take risks. In a combined sample of over 1
million individuals, we conducted genome-wide association studies (GWAS) of general risk …
million individuals, we conducted genome-wide association studies (GWAS) of general risk …
Mitochondrial double-stranded RNA triggers antiviral signalling in humans
Mitochondria are descendants of endosymbiotic bacteria and retain essential prokaryotic
features such as a compact circular genome. Consequently, in mammals, mitochondrial …
features such as a compact circular genome. Consequently, in mammals, mitochondrial …
Bioinformatics methods for mass spectrometry-based proteomics data analysis
Recent advances in mass spectrometry (MS)-based proteomics have enabled tremendous
progress in the understanding of cellular mechanisms, disease progression, and the …
progress in the understanding of cellular mechanisms, disease progression, and the …