Therapeutic drug monitoring (TDM) is the quantification and interpretation of drug
concentrations in blood to optimize pharmacotherapy. It considers the interindividual …

Therapeutic drug monitoring (TDM), ie, the quantification of serum or plasma concentrations
of medications for dose optimization, has proven a valuable tool for the patient-matched …

There are significant differences between men and women in the efficacy and tolerability of
antipsychotic drugs. Here, we provide a comprehensive overview of what is currently known …

Aging is characterized by a progressive loss of functional capacities of most if not all organs,
a reduction in homeostatic mechanisms, and a response to receptor stimulation. Also, loss of …

Objective To investigate serum concentrations of second‐generation antipsychotics in
relation to age and gender in a population ranging from 18 to 100 years. Method Results …

Context: The health burden of antipsychotic medication is well known, but the
disproportionate effect on women as compared with men is underappreciated. Objective …

Background: The activity of various CYP isoforms is critical for maintaining the clinical
effectiveness of many medications. Therefore, determining the sex-dependent activity of …

The association between drugs and falls has been widely studied in the past 3 decades,
with increasingly robust evidence of a causal link. Both specific classes of drugs and the …

The functional role of cytochrome P450 (CYP) enzymes in the brain is an exciting and
evolving field of research. CYPs are present and active in the brain, with heterogeneous …

Six second-generation antipsychotics (SGAs), aripiprazole, clozapine, olanzapine,
quetiapine, risperidone and ziprasidone, are currently US FDA approved. The aim of this …