Testicular cancer
Testicular cancer is the most common malignancy among men between 14 and 44 years of
age, and its incidence has risen over the past two decades in Western countries. Both …
age, and its incidence has risen over the past two decades in Western countries. Both …
Genome-wide association studies of cancer: current insights and future perspectives
Genome-wide association studies (GWAS) provide an agnostic approach for investigating
the genetic basis of complex diseases. In oncology, GWAS of nearly all common …
the genetic basis of complex diseases. In oncology, GWAS of nearly all common …
Genetic predisposition to mosaic Y chromosome loss in blood
Mosaic loss of chromosome Y (LOY) in circulating white blood cells is the most common
form of clonal mosaicism,,,–, yet our knowledge of the causes and consequences of this is …
form of clonal mosaicism,,,–, yet our knowledge of the causes and consequences of this is …
Human germ cell tumours from a developmental perspective
JW Oosterhuis, LHJ Looijenga - Nature Reviews Cancer, 2019 - nature.com
Human germ cell tumours (GCTs) are derived from stem cells of the early embryo and the
germ line. They occur in the gonads (ovaries and testes) and also in extragonadal sites …
germ line. They occur in the gonads (ovaries and testes) and also in extragonadal sites …
Promoter-interacting expression quantitative trait loci are enriched for functional genetic variants
Expression quantitative trait loci (eQTLs) studies provide associations of genetic variants
with gene expression but fall short of pinpointing functionally important eQTLs. Here, using …
with gene expression but fall short of pinpointing functionally important eQTLs. Here, using …
Testicular germ cell tumor: a comprehensive review
A Batool, N Karimi, XN Wu, SR Chen, YX Liu - Cellular and Molecular Life …, 2019 - Springer
Testicular tumors are the most common tumors in adolescent and young men and germ cell
tumors (TGCTs) account for most of all testicular cancers. Increasing incidence of TGCTs …
tumors (TGCTs) account for most of all testicular cancers. Increasing incidence of TGCTs …
Cytokines in male fertility and reproductive pathologies: immunoregulation and beyond
Germline development in vivo is dependent on the environment formed by somatic cells and
the differentiation cues they provide; hence, the impact of local factors is highly relevant to …
the differentiation cues they provide; hence, the impact of local factors is highly relevant to …
Human germ cell tumors are developmental cancers: impact of epigenetics on pathobiology and clinic
Current (high throughput omics-based) data support the model that human (malignant) germ
cell tumors are not initiated by somatic mutations, but, instead through a defined locked …
cell tumors are not initiated by somatic mutations, but, instead through a defined locked …
Assessment of polygenic architecture and risk prediction based on common variants across fourteen cancers
Genome-wide association studies (GWAS) have led to the identification of hundreds of
susceptibility loci across cancers, but the impact of further studies remains uncertain. Here …
susceptibility loci across cancers, but the impact of further studies remains uncertain. Here …
Application of miRNAs in the diagnosis and monitoring of testicular germ cell tumours
Testicular germ cell tumours (TGCTs) are the most frequent cancer type in young men and
originate from the common precursor germ cell neoplasia in situ (GCNIS). For decades …
originate from the common precursor germ cell neoplasia in situ (GCNIS). For decades …