Zebrafish are teleosts (bony fish) that share with mammals a common ancestor belonging to
the phylum Osteichthyes, from which their endoskeletal systems have been inherited …

Animal models are essential tools for addressing fundamental scientific questions about
skeletal diseases and for the development of new therapeutic approaches. Traditionally …

Osteoporosis is metabolic bone disease caused by an altered balance between bone
anabolism and catabolism. This dysregulated balance is responsible for fragile bones that …

During embryogenesis, the musculoskeletal system develops while containing within itself a
force generator in the form of the musculature. This generator becomes functional relatively …

Craniofacial secondary cartilages of the mandibular condyle and temporomandibular joint
(TMJ) eminence grow in response to the local mechanical environment. The intervening …

The identification of disease-causing mutations has in recent years progressed immensely
due to whole genome sequencing approaches using patient material. The task accordingly …

Synovial joints, characterized by reciprocally congruent and lubricated articular surfaces
separated by a cavity, can simultaneously provide mobility and load bearing. Here, we study …

Signal transmission from the mechanical forces to the various intracellular activities is a
fundamental process during tissue development. Despite their critical role, the mechanism of …

Wnts are secreted cysteine-rich glycoproteins involved in joint development and skeletal
homeostasis and have been implicated in the occurrence of osteoarthritis. Over the past …

Back pain is a common condition with a high social impact and represents a global health
burden. Intervertebral disc disease (IVDD) is one of the major causes of back pain; no …