The complexity of Alzheimer's disease: an evolving puzzle
The history of Alzheimer's disease (AD) started in 1907, but we needed to wait until the end
of the century to identify the components of pathological hallmarks and genetic subtypes and …
of the century to identify the components of pathological hallmarks and genetic subtypes and …
Dissecting the clinical heterogeneity of early-onset Alzheimer's disease
Early-onset Alzheimer's disease (EOAD) is a rare but particularly devastating form of AD.
Though notable for its high degree of clinical heterogeneity, EOAD is defined by the same …
Though notable for its high degree of clinical heterogeneity, EOAD is defined by the same …
Early-onset Alzheimer's disease: what is missing in research?
Abstract Purpose of Review Early-onset Alzheimer's disease (EOAD), defined as
Alzheimer's disease (AD) occurring before age 65, is significantly less well studied than the …
Alzheimer's disease (AD) occurring before age 65, is significantly less well studied than the …
Defeating Alzheimer's disease and other dementias: a priority for European science and society
Executive summary Alzheimer's disease (AD) is the leading cause of dementia, and
because the primary risk factor for AD is old age, the prevalence of the disease is increasing …
because the primary risk factor for AD is old age, the prevalence of the disease is increasing …
APP, PSEN1, and PSEN2 mutations in early-onset Alzheimer disease: A genetic screening study of familial and sporadic cases
Background Amyloid protein precursor (APP), presenilin-1 (PSEN1), and presenilin-2
(PSEN2) mutations cause autosomal dominant forms of early-onset Alzheimer disease (AD …
(PSEN2) mutations cause autosomal dominant forms of early-onset Alzheimer disease (AD …
The genetic landscape of Alzheimer disease: clinical implications and perspectives
C Van Cauwenberghe, C Van Broeckhoven… - Genetics in …, 2016 - nature.com
The search for the genetic factors contributing to Alzheimer disease (AD) has evolved
tremendously throughout the years. It started from the discovery of fully penetrant mutations …
tremendously throughout the years. It started from the discovery of fully penetrant mutations …
Cholesterol metabolism and homeostasis in the brain
J Zhang, Q Liu - Protein & cell, 2015 - academic.oup.com
Cholesterol is an essential component for neuronal physiology not only during development
stage but also in the adult life. Cholesterol metabolism in brain is independent from that in …
stage but also in the adult life. Cholesterol metabolism in brain is independent from that in …
Cholesterol metabolism in neurodegenerative diseases: molecular mechanisms and therapeutic targets
L Dai, L Zou, L Meng, G Qiang, M Yan, Z Zhang - Molecular neurobiology, 2021 - Springer
Cholesterol is an indispensable component of the cell membrane and plays vital roles in
critical physiological processes. Brain cholesterol accounts for a large portion of total …
critical physiological processes. Brain cholesterol accounts for a large portion of total …
[HTML][HTML] Genetics of Alzheimer's disease: where we are, and where we are going
C Bellenguez, B Grenier-Boley, JC Lambert - Current opinion in …, 2020 - Elsevier
Highlights•More than 40 loci of interest have been associated with the risk of develo**
AD.•Recent genetic data clearly implicate microglia as involved in the pathophysiological …
AD.•Recent genetic data clearly implicate microglia as involved in the pathophysiological …
Genetic architectures of psychiatric disorders: the emerging picture and its implications
Psychiatric disorders are among the most intractable enigmas in medicine. In the past 5
years, there has been unprecedented progress on the genetics of many of these conditions …
years, there has been unprecedented progress on the genetics of many of these conditions …