The simplest peptide structural element is the peptide β-strand. The β-strand is a linear or
sawtoothed arrangement of amino acids with amide bonds being almost coplanar, side …

Inherited and somatic mutations in the adenomatous polyposis coli occur in most colon
cancers, leading to activation of β-catenin-responsive genes. To identify small molecule …

Chemical genomics is a powerful method to complement more traditional genetic
techniques (ie knockout mice, siRNA) for the dissection of complex signaling networks. Wnt …

The development of rational methods to design 'continuous' sequence mimetics of
discontinuous regions of protein sequence has, to now, been only marginally successful …

Release of human lung mast cell tryptase may be important in the pathophysiology of
asthma. We examined the effect of the reversible, nonelectrophilic tryptase inhibitor MOL …

Asthma is characterized by an oxidant/antioxidant imbalance in the lungs leading to
activation of redox-sensitive transcription factors, nuclear factor κB (NF-κB), and activator …

New ligands for a variety of biological targets can be selected from biological or synthetic
combinatorial peptide libraries. The use of different libraries to select novel peptides with …

A review. The use of. beta.-strand mimetics has expanded in recent years to include
compds. developed for protein-protein interactions involving many types of protease …

Monosaccharides provide an excellent platform to tailor molecular diversity by appending
desired substituents at selected positions around the sugar scaffold. The presence of five …

Background & Aims: We studied the role of protease-activated receptor 2 (PAR2) and its
activating enzymes, trypsins and tryptase, in Clostridium difficile toxin A (TxA)-induced …