Coronary artery calcification: from mechanism to molecular imaging

T Nakahara, MR Dweck, N Narula, D Pisapia… - JACC: Cardiovascular …, 2017 - jacc.org
Vascular calcification is a hallmark of atherosclerosis. The location, density, and confluence
of calcification may change portions of the arterial conduit to a noncompliant structure …

Calcification in atherosclerotic plaque vulnerability: friend or foe?

X Shi, J Gao, Q Lv, H Cai, F Wang, R Ye… - Frontiers in physiology, 2020 - frontiersin.org
Calcification is a clinical marker of atherosclerosis. This review focuses on recent findings on
the association between calcification and plaque vulnerability. Calcified plaques have …

[HTML][HTML] 18F-fluoride positron emission tomography for identification of ruptured and high-risk coronary atherosclerotic plaques: a prospective clinical trial

NV Joshi, AT Vesey, MC Williams, ASV Shah… - The Lancet, 2014 - thelancet.com
Background The use of non-invasive imaging to identify ruptured or high-risk coronary
atherosclerotic plaques would represent a major clinical advance for prevention and …

Identifying active vascular microcalcification by 18F-sodium fluoride positron emission tomography

A Irkle, AT Vesey, DY Lewis, JN Skepper… - Nature …, 2015 - nature.com
Vascular calcification is a complex biological process that is a hallmark of atherosclerosis.
While macrocalcification confers plaque stability, microcalcification is a key feature of high …

Coronary arterial 18F-sodium fluoride uptake: a novel marker of plaque biology

MR Dweck, MWL Chow, NV Joshi, MC Williams… - Journal of the American …, 2012 - jacc.org
Objectives: With combined positron emission tomography and computed tomography (CT),
we investigated coronary arterial uptake of 18F-sodium fluoride (18F-NaF) and 18F …

Calcific aortic valve stenosis: hard disease in the heart: a biomolecular approach towards diagnosis and treatment

FECM Peeters, SJR Meex, MR Dweck… - European heart …, 2018 - academic.oup.com
Calcific aortic valve stenosis (CAVS) is common in the ageing population and set to become
an increasing economic and health burden. Once present, it inevitably progresses and has a …

Position paper of the Cardiovascular Committee of the European Association of Nuclear Medicine (EANM) on PET imaging of atherosclerosis

J Bucerius, F Hyafil, HJ Verberne, RHJA Slart… - European journal of …, 2016 - Springer
Cardiovascular diseases are the leading cause of death not only in Europe but also in the
rest of the World. Preventive measures, however, often fail and cardiovascular disease may …

Assessment of valvular calcification and inflammation by positron emission tomography in patients with aortic stenosis

MR Dweck, C Jones, NV Joshi, AM Fletcher… - Circulation, 2012 - ahajournals.org
Background—The pathophysiology of aortic stenosis is incompletely understood, and the
relative contributions of valvular calcification and inflammation to disease progression are …

Cardiovascular calcification: artificial intelligence and big data accelerate mechanistic discovery

MA Rogers, E Aikawa - Nature Reviews Cardiology, 2019 - nature.com
Cardiovascular calcification is a health disorder with increasing prevalence and high
morbidity and mortality. The only available therapeutic options for calcific vascular and …

18F-sodium fluoride uptake is a marker of active calcification and disease progression in patients with aortic stenosis

MR Dweck, WSA Jenkins, AT Vesey… - Circulation …, 2014 - ahajournals.org
Background—18F-Sodium fluoride (18F-NaF) and 18F-fluorodeoxyglucose (18F-FDG) are
promising novel biomarkers of disease activity in aortic stenosis. We compared 18F-NaF …