Antimicrobial drug resistance is threatening to take us to the “pre‐antibiotic era”, where
people are dying from preventable and treatable diseases and the risk of hospital …

The ability to overcome metabolic stress is a major determinant of outcomes during
infections. Pathogens face nutrient and oxygen deprivation in host niches and during their …

The opportunistic fungal pathogen Candida albicans thrives on human mucosal surfaces as
a harmless commensal, but frequently causes infections under certain predisposing …

Patients with decreased levels of CD18 (β2 integrins) suffer from life-threatening bacterial
and fungal infections. CD11b, the α subunit of integrin CR3 (CD11b/CD18, αMβ2), is …

The opportunistic fungal pathogen Candida albicans acquires essential metals from the
host, yet the host can sequester these micronutrients through a process known as nutritional …

The outcome of fungal infections depends on interactions with innate immune cells. Within a
population of macrophages encountering Candida albicans, there are distinct host …

Candida albicans bloodstream infection causes fungal septicaemia and death in over half of
afflicted patients. Polymorphonuclear leukocytes (PMN) mediate defense against invasive …

Our immune system possesses sophisticated mechanisms to cope with invading
microorganisms, while pathogens evolve strategies to deal with threats imposed by host …

Nutritional immunity describes the host-driven manipulation of essential micronutrients,
including iron, zinc and manganese. To withstand nutritional immunity and proliferate within …

Immune cells, including macrophages and monocytes, remodel their metabolism and have
specific nutritional needs when dealing with microbial pathogens. While we are just …