In this review we attempt to summarize experimental evidence on the existence of defined
native GABA A receptor subtypes and to produce a list of receptors that actually seem to …

Cl− channels reside both in the plasma membrane and in intracellular organelles. Their
functions range from ion homeostasis to cell volume regulation, transepithelial transport, and …

GABAA receptors are ligand-operated chloride channels assembled from five subunits in a
heteropentameric manner. Using immunocytochemistry, we investigated the distribution of …

GABA-A receptors are the major inhibitory neurotransmitter receptors in the brain and are
the site of action of many clinically important drugs. These receptors are composed of five …

GABAA‐receptors display an extensive structural heterogeneity based on the differential
assembly of a family of at least 15 subunits (α1–6, β1–3, γ1–3, θ, ρl–2) into distinct …

Fear is an adaptive component of the acute “stress” response to potentially-dangerous
(external and internal) stimuli which threaten to perturb homeostasis. However, when …

Aging and acoustic trauma may result in partial peripheral deafferentation in the central
auditory pathway of the mammalian brain. In accord with homeostatic plasticity, loss of …

The amino acid γ-aminobutyric-acid (GABA) prevails in the CNS as an inhibitory neurotrans-
mitter that mediates most of its effects through fast GABA-gated Cl−-channels (GABA AR) …

Recent advances in molecular biology and complementary information derived from
neuropharmacology, biochemistry and behavior have dramatically increased our …

The γ-aminobutyric acid (GABA) type A receptor system, the main fast-acting inhibitory
neurotransmitter system in the brain, is the pharmacological target for many drugs used …