Genetic origins, regulators, and biomarkers of cellular senescence

G Torres, IA Salladay-Perez, A Dhingra… - Trends in Genetics, 2024 - cell.com
This review comprehensively examines the molecular biology and genetic origins of cellular
senescence. We focus on various cellular stressors and pathways leading to senescence …

Biomarkers of cellular senescence and aging: current state‐of‐the‐art, challenges and future perspectives

S Muthamil, HY Kim, HJ Jang, JH Lyu… - Advanced …, 2024 - Wiley Online Library
Population aging has increased the global prevalence of aging‐related diseases, including
cancer, sarcopenia, neurological disease, arthritis, and heart disease. Understanding aging …

Subcellular structure, heterogeneity, and plasticity of senescent cells

TC Bitencourt, JE Vargas, AO Silva, LR Fraga… - Aging …, 2024 - Wiley Online Library
Cellular senescence is a state of permanent growth arrest. It can be triggered by telomere
shortening (replicative senescence) or prematurely induced by stresses such as DNA …

[HTML][HTML] Senescence and fibrosis in salivary gland aging and disease

DA Nelson, I Kazanjian, JA Melendez… - Journal of Oral Biology and …, 2024 - Elsevier
Salivary gland hypofunction is highly prevalent in aged and diseased individuals leading to
significant discomfort and morbidity. One factor that contributes to salivary gland …

Novel PET Imaging Probe for Quantitative Detection of Senescence In Vivo

X **ang, C Dong, L Zhou, J Liu… - Journal of Medicinal …, 2024 - ACS Publications
Real-time detection of cellular senescence remains a clinical challenge. Here, we aimed to
develop a positron emission tomography (PET) imaging probe targeting senescence …

[HTML][HTML] Hallmarks of aging: A user's guide for comparative biologists

PR Biga, JE Duan, TE Young, JR Marks… - Ageing Research …, 2025 - Elsevier
Since the first description of a set of characteristics of aging as so-called hallmarks or pillars
in 2013/2014, these characteristics have served as guideposts for the research in aging …

Emerging insights in senescence: pathways from preclinical models to therapeutic innovations

L Mansfield, V Ramponi, K Gupta, T Stevenson… - npj Aging, 2024 - nature.com
Senescence is a crucial hallmark of ageing and a significant contributor to the pathology of
age-related disorders. As committee members of the young International Cell Senescence …

The role of Biophotons in cellular senescence.

I Kalampouka - 2024 - westminsterresearch.westminster.ac …
Senescence is the irreversible arrest of cell proliferation. While serving as a natural barrier
against mutation progression, senescence's metabolic activity and elevated ROS levels can …

Advancements in Instrumentation, Eye Tracking, and Imaging Techniques for Enhanced Retinal Imaging: Innovations and Applications

AH Patel - 2024 - search.proquest.com
Retinal imaging, the process of capturing detailed images of the retina has evolved
significantly over time with advancements and innovations in optics, electronics, software …

[PDF][PDF] Modificaciones en la activación del receptor TLR4 durante la senescencia de las células cebadas: participación de la cinasa Lyn

DL Esparza Reyes - 2024 - repositorio.cinvestav.mx
A la Dra. Iris Karina Madera Salcedo por las enseñanzas en técnicas y análisis de datos de
citometría de flujo, por la paciencia y la disposición de entrenamiento. Muchas gracias por …