Functional and pathological roles of adenylyl cyclases in various diseases
Y Gao, Y Luo, G Ji, T Wu - International Journal of Biological …, 2024 - Elsevier
Adenylyl cyclases (ADCYs) produce the second messengers cAMP, which is crucial for a
number of cellular activities. There are ten isoforms in the mammalian ADCY family …
number of cellular activities. There are ten isoforms in the mammalian ADCY family …
Soluble cyclase-mediated nuclear cAMP synthesis is sufficient for cell proliferation
cAMP, a key player in many physiological processes, was classically considered to originate
solely from the plasma membrane (PM). This view was recently challenged by observations …
solely from the plasma membrane (PM). This view was recently challenged by observations …
Highly-Sensitive In Vitro Bioassays for FSH, TSH, PTH, Kp, and OT in Addition to LH in Mouse Leydig Tumor Cell
We demonstrate here that highly sensitive in vitro bioassays for FSH, TSH, and PTH can be
set up in mouse Leydig Tumor Cells (mLTC), in addition to the normal LH/CG bioassay, after …
set up in mouse Leydig Tumor Cells (mLTC), in addition to the normal LH/CG bioassay, after …
Identification of the Role of TGR5 in the Regulation of Leydig Cell Homeostasis
H Holota, A De Haze, E Martinot, M Monrose… - International Journal of …, 2022 - mdpi.com
Understanding the regulation of the testicular endocrine function leading to testosterone
production is a major objective as the alteration of endocrine function is associated with the …
production is a major objective as the alteration of endocrine function is associated with the …
Role of Intracellular Divalent Cations on the Adenylate Cyclase Activation by Human LH in mLTC-1 Leydig Cells
Introduction: The Luteinizing Hormone (LH) regulates Leydig cell activities through LHR
occupation, promoting Gs protein and/or β-arrestin activation. The activated GsαGTP subunit …
occupation, promoting Gs protein and/or β-arrestin activation. The activated GsαGTP subunit …
Roles of Soluble Adenylyl Cyclase in cAMP Synthesis in Animal Cells
The second messenger cyclic adenosine 3†², 5†²-monophosphate (cAMP) synthesis is
catalyzed by adenylyl cyclases (ACs). The second messenger cAMP participates in many …
catalyzed by adenylyl cyclases (ACs). The second messenger cAMP participates in many …