Genotype× environment interactions (GxE) have long been recognized as a key mechanism
underlying human phenotypic variation. Technological developments over the past 15 years …

Humans exhibit considerable variability in their immune responses to the same immune
challenges. Such variation is widespread and affects individual and population‐level …

Genetic effects on gene expression and splicing can be modulated by cellular and
environmental factors; yet interactions between genotypes, cell type, and treatment have not …

Leprosy is a chronic infectious disease of the skin and peripheral nerves that presents a
strong link with the host genetic background. Different approaches in genetic studies have …

One life-threatening outcome of cardiovascular disease is myocardial infarction, where
cardiomyocytes are deprived of oxygen. To study inter-individual differences in response to …

Mycolactone, a lipid-like toxin, is the major virulence factor of Mycobacterium ulcerans, the
etiological agent of Buruli ulcer. Its involvement in lesion development has been widely …

Human alveolar macrophages (HAM) are primary bacterial niche and immune response
cells during Mycobacterium tuberculosis (M. tb) infection, and human blood monocyte …

Genome-wide association studies (GWASs) and genome-wide linkage studies (GWLSs)
have identified numerous risk genes affecting the susceptibility to leprosy. However, most of …

Synthetic glucocorticoids, such as dexamethasone, have been used as a treatment for many
immune conditions, such as asthma and, more recently, severe COVID-19. Single-cell data …

To date, genome‐wide association studies (GWASs) have discovered 35 susceptible loci of
leprosy; however, the cumulative effects of these loci can only partially explain the overall …