The evidence is now fairly conclusive that collagen-induced arthritis in rodents is mediated
by antitype II collagen autoimmunity. Arthritis is probably initiated by binding of antibodies to …

The cause and pathogenesis of many of the chronic diseases afflicting man remain much of
a mystery: it has been necessary therefore to model such conditions in experimental animals …

Antibodies against type II collagen (anti-CII) are arthritogenic and have a crucial role in the
initiation of collagen-induced arthritis. Here, we have determined the dependence of T and B …

A PROMINENT histologic feature in sections of synovial lining is the layer of cells on the
internal surface of this tissue. The function of these synovial lining cells (SLCs) in the normal …

Rats were per-gastrically dosed by gavage with collagen type II (CII) in solution and were
shown, as a result, to be subsequently resistant to the induction of disease by CII …

Ocular inflammatory disease is the third leading cause of blindness in the United States. In
addition to the conventional immunomodulatory agents, which include antimetabolites …

Objective Previous randomized controlled trials for treatment of rheumatoid arthritis (RA)
with acid‐soluble chicken and bovine type II collagen (CII) have produced conflicting results …

We set out to determine whether inhibition of complement using sCR1 could influence the
development and progression of collagen arthritis in the Lewis rat. Collagen arthritis was …

The oral administration of CII by gavage to WA/KIR rats before a conventional arthritogenic
challenge with bovine CII in FIA reduced the incidence (by 23%) and delayed the onset of …

The passive transfer of high levels of anti‐type II collagen antibody from mice with type II
collagen‐induced arthritis may transfer arthritis to syngeneic recipient animals. However, the …