[HTML][HTML] Melatonin reduces β-amyloid accumulation and improves short-term memory in streptozotocin-induced sporadic Alzheimer's disease model

MK Andrade, LC Souza, EM Azevedo, EL Bail… - IBRO Neuroscience …, 2023 - Elsevier
Melatonin is a hormone secreted by the pineal gland, it can be associated with circadian
rhythms, aging and neuroprotection. Melatonin levels are decreased in sporadic Alzheimer's …

Disbalance of the duodenal epithelial cell turnover and apoptosis accompanies insensitivity of intestinal redox homeostasis to inhibition of the brain glucose …

J Homolak, A Babic Perhoc, A Knezovic… - …, 2022 - karger.com
Introduction: Gastrointestinal dyshomeostasis is investigated in the context of metabolic
dysfunction, systemic, and neuroinflammation in Alzheimer's disease. Dysfunctional …

From attention-deficit hyperactivity disorder to sporadic Alzheimer's disease—Wnt/mTOR pathways hypothesis

E Grünblatt, J Homolak, A Babic Perhoc… - Frontiers in …, 2023 - frontiersin.org
Alzheimer's disease (AD) is the most common neurodegenerative disorder with the majority
of patients classified as sporadic AD (sAD), in which etiopathogenesis remains unresolved …

Altered secretion, constitution, and functional properties of the gastrointestinal mucus in a rat model of sporadic alzheimer's disease

J Homolak, J De Busscher… - ACS Chemical …, 2023 - ACS Publications
The gastrointestinal (GI) system is affected in Alzheimer's disease (AD); however, it is
currently unknown whether GI alterations arise as a consequence of central nervous system …

Failure of the brain glucagon-like peptide-1-mediated control of intestinal redox homeostasis in a rat model of sporadic Alzheimer's disease

J Homolak, A Babic Perhoc, A Knezovic… - Antioxidants, 2021 - mdpi.com
The gastrointestinal system may be involved in the etiopathogenesis of the insulin-resistant
brain state (IRBS) and Alzheimer's disease (AD). Gastrointestinal hormone glucagon-like …

Is galactose a hormetic sugar? An exploratory study of the rat hippocampal redox regulatory network

J Homolak, A Babic Perhoc, A Knezovic… - Molecular Nutrition & …, 2021 - Wiley Online Library
Scope Galactose, a ubiquitous monosaccharide with incompletely understood physiology is
often exploited for inducing oxidative‐stress mediated aging in animals. Recent research …

Melatonin improves cognitive dysfunction and decreases gliosis in the streptozotocin-induced rat model of sporadic Alzheimer's disease

Z Gáll, B Boros, K Kelemen, M Urkon… - Frontiers in …, 2024 - frontiersin.org
Introduction Alzheimer's disease (AD) and other forms of dementia have a devastating effect
on the community and healthcare system, as neurodegenerative diseases are causing …

Insights into Gastrointestinal Redox Dysregulation in a Rat Model of Alzheimer's Disease and the Assessment of the Protective Potential of D-Galactose

J Homolak, K Varvaras, V Sciacca, A Babic Perhoc… - ACS …, 2024 - ACS Publications
Recent evidence suggests that the gut plays a vital role in the development and progression
of Alzheimer's disease (AD) by triggering systemic inflammation and oxidative stress. The …

Experimental approach to Alzheimer's disease with emphasis on insulin resistance in the brain

M Salkovic-Petrisic, AB Perhoc, J Homolak… - Handbook of …, 2023 - Springer
This chapter on current experimental models of Alzheimer's disease (AD) is based on
human post-mortem findings showing keystone markers for pathology within the ß-amyloid …

My friend MIROSLAV: A Hackable Open-Source Hardware and Software Platform for High-Throughput Rodent Activity Monitoring in the Home Cage

D Virag, J Homolak, I Kodvanj, AM Vargantolić… - bioRxiv, 2024 - biorxiv.org
While conventional behavioural tests offer valuable insight into rodent behaviour in specific
paradigms, rodents spend most of their time in a safe, undisturbed environment–their home …