The aggregation of alpha-synuclein (aSyn) represents a neuropathological hallmark
observed in a group of neurodegenerative disorders collectively known as …

Phase separation is a thermodynamic process leading to the formation of compositionally
distinct phases. For the past few years, numerous works have shown that biomolecular …

Alpha-synuclein (aSyn) pathology is present in approximately 50% of Alzheimer's disease
(AD) cases at autopsy and might impact the age-of-onset and disease progression in AD …

Synucleinopathies, including Parkinson's disease, dementia with Lewy bodies, and multiple
system atrophy, are triggered by α-synuclein aggregation, triggering progressive …

The etiology of Parkinson's disease is poorly understood and is most commonly associated
with advancing age, genetic predisposition, or environmental toxins. Epidemiological …

Lewy body disorders are heterogeneous neurological conditions defined by intracellular
inclusions composed of misshapen α-synuclein protein aggregates. Although α-synuclein …

Synaptic vesicle (SV) clusters, which reportedly result from synapsin's capacity to undergo
liquid-liquid phase separation (LLPS), constitute the structural basis for neurotransmission …

Over the past decade, myriads of studies have highlighted the central role of protein
condensation in subcellular compartmentalization and spatiotemporal organization of …

Bloodworm jaws are composites of protein, melanin, and both mineral and ionic copper. To
date, nanomechanical tests have correlated the ionic copper and melanin with hardness …

Accumulation of protein aggregates is a hallmark of cellular aging and degenerative
disorders. This could result from either increased protein misfolding and aggregation or …