Stressful stimuli in healthy subjects trigger activation of a consistent and reproducible set of
brain regions; yet, the notion that there is a single and constant stress neuromatrix is not …

Maladaptive responses to stress and the associated hypersecretion of glucocorticoids cause
psychopathologies ranging from hyperemotional states and mood dysfunction to cognitive …

Adverse early life events can induce long-lasting changes in physiology and behavior. We
found that early-life stress (ELS) in mice caused enduring hypersecretion of corticosterone …

Ketamine treatment decreases depressive symptoms within hours, but the mechanisms
mediating these rapid antidepressant effects are unclear. Here, we demonstrate that activity …

Alzheimer's disease (AD) involves progressive accumulation of amyloid β-peptide (Aβ) and
neurofibrillary pathologies, and glucose hypometabolism in brain regions critical for …

Exposure to chronic stress can have broad effects on health ranging from increased
predisposition for neuropsychiatric disorders to deregulation of immune responses. The …

Chronic stress is a major risk factor for several human disorders that affect modern societies.
The brain is a key target of chronic stress. In fact, there is growing evidence indicating that …

Serotonin is a major neurotransmitter in the central nervous system (CNS). Dysregulation of
serotonin transmission in the CNS is reported to be related to different psychiatric disorders …

Objective: To identify the impact of timing of prenatal stress exposure on offspring risk for
shortened gestational age, preterm birth (PTB), low birth weight (LBW), and small for …

Exposure to chronic stress is frequently accompanied by cognitive and affective disorders in
association with neurostructural adaptations. Chronic stress was previously shown to trigger …