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Acylcarnitines: nomenclature, biomarkers, therapeutic potential, drug targets, and clinical trials
Acylcarnitines are fatty acid metabolites that play important roles in many cellular energy
metabolism pathways. They have historically been used as important diagnostic markers for …
metabolism pathways. They have historically been used as important diagnostic markers for …
Capillary electrophoresis: trends and recent advances
Since the introduction of modern capillary electrophoresis (CE) by Jorgenson and Lukacs in
1981, CE has evolved into a highly mature and versatile separation technique. After a first …
1981, CE has evolved into a highly mature and versatile separation technique. After a first …
Current and future perspectives of functional metabolomics in disease studies–A review
Functional metabolomics is a new concept, which studies the functions of metabolites and
related enzymes focused on metabolomics. It overcomes the shortcomings of traditional …
related enzymes focused on metabolomics. It overcomes the shortcomings of traditional …
Recent advances in CE‐MS coupling: Instrumentation, methodology, and applications
A Týčová, V Ledvina, K Klepárník - Electrophoresis, 2017 - Wiley Online Library
This review focuses on the latest development of microseparation electromigration methods
in capillaries and microfluidic devices coupled with MS for detection and identification of …
in capillaries and microfluidic devices coupled with MS for detection and identification of …
Capillary electrophoresis mass spectrometry as a tool for untargeted metabolomics
Highly polar and ionic metabolites, such as sugars, most amino acids, organic acids or
nucleotides are not retained by conventional reversed-phase LC columns and polar …
nucleotides are not retained by conventional reversed-phase LC columns and polar …
Enhancing confidence of metabolite annotation in Capillary Electrophoresis-Mass Spectrometry untargeted metabolomics with relative migration time and in-source …
Capillary electrophoresis coupled to mass spectrometry is a power tool in untargeted
metabolomics studies to analyze charged and polar compounds. However, identification is a …
metabolomics studies to analyze charged and polar compounds. However, identification is a …
New insight into primary hyperparathyroidism using untargeted metabolomics
Primary Hyperparathyroidism (PHPT) is characterized by excessive parathormone (PTH)
secretion and disrupted calcium homeostasis. Untargeted metabolomics offers a valuable …
secretion and disrupted calcium homeostasis. Untargeted metabolomics offers a valuable …
Development of a sheathless CE‐ESI‐MS interface
A Hirayama, H Abe, N Yamaguchi, S Tabata… - …, 2018 - Wiley Online Library
A sheath‐flow interface is the most common ionization technique in CE‐ESI‐MS. However,
this interface dilutes the analytes with the sheath liquid and decreases the sensitivity. In this …
this interface dilutes the analytes with the sheath liquid and decreases the sensitivity. In this …
An exploratory LC‐MS‐based metabolomics study reveals differences in aqueous humor composition between diabetic and non‐diabetic patients with cataract
Cataract is the leading cause of blindness worldwide. Epidemiological studies revealed up
to a fivefold increased prevalence of cataracts in diabetic subjects. Metabolomics is …
to a fivefold increased prevalence of cataracts in diabetic subjects. Metabolomics is …
[HTML][HTML] The role of muscle decline in type 2 diabetes development: a 5-year prospective observational cohort study
K Maliszewska, E Adamska-Patruno, J Goscik… - Nutrients, 2019 - mdpi.com
The major risk factors of T2DM (type 2 diabetes mellitus) development are still under
investigation. We evaluate the possible risk factors associated with type 2 diabetes (T2DM) …
investigation. We evaluate the possible risk factors associated with type 2 diabetes (T2DM) …