Neutrophil extracellular traps in immunity and disease

V Papayannopoulos - Nature Reviews Immunology, 2018 - nature.com
Neutrophils are innate immune phagocytes that have a central role in immune defence. Our
understanding of the role of neutrophils in pathogen clearance, immune regulation and …

Cellular mechanisms of NETosis

HR Thiam, SL Wong, DD Wagner… - Annual review of cell …, 2020 - annualreviews.org
Neutrophils are critical to innate immunity, including host defense against bacterial and
fungal infections. They achieve their host defense role by phagocytosing pathogens …

Neutrophil extracellular traps: from physiology to pathology

A Hidalgo, P Libby, O Soehnlein… - Cardiovascular …, 2022 - academic.oup.com
At the frontline of the host defence response, neutrophil antimicrobial functions have
adapted to combat infections and injuries of different origins and magnitude. The release of …

Diverse stimuli engage different neutrophil extracellular trap pathways

EF Kenny, A Herzig, R Krüger, A Muth, S Mondal… - Elife, 2017 - elifesciences.org
Neutrophils release neutrophil extracellular traps (NETs) which ensnare pathogens and
have pathogenic functions in diverse diseases. We examined the NETosis pathways …

Beyond hemostasis: platelet innate immune interactions and thromboinflammation

J Mandel, M Casari, M Stepanyan, A Martyanov… - International journal of …, 2022 - mdpi.com
There is accumulating evidence that platelets play roles beyond their traditional functions in
thrombosis and hemostasis, eg, in inflammatory processes, infection and cancer, and that …

SK3 channel and mitochondrial ROS mediate NADPH oxidase-independent NETosis induced by calcium influx

DN Douda, MA Khan, H Grasemann… - Proceedings of the …, 2015 - National Acad Sciences
Neutrophils cast neutrophil extracellular traps (NETs) to defend the host against invading
pathogens. Although effective against microbial pathogens, a growing body of literature now …

Neutrophil extracellular traps participate in cardiovascular diseases: recent experimental and clinical insights

Y Döring, P Libby, O Soehnlein - Circulation research, 2020 - Am Heart Assoc
Neutrophil extracellular traps (NETs) have recently emerged as a newly recognized
contributor to venous and arterial thrombosis. These strands of DNA extruded by activated or …

Neutrophil extracellular traps in the pathology of cancer and other inflammatory diseases

M Herre, J Cedervall, N Mackman… - Physiological …, 2023 - journals.physiology.org
Neutrophil extracellular trap (NET) formation, first described in 2004 as a previously
unknown strategy of neutrophils to fight microbes, has attracted an increasing interest in the …

Neutrophil extracellular traps: the biology of chromatin externalization

G Sollberger, DO Tilley, A Zychlinsky - Developmental cell, 2018 - cell.com
Neutrophils are essential to the homeostatic mission of safeguarding host tissues,
responding rapidly and diversely to breaches of the host's barriers to infection, and returning …

Neutrophil extracellular traps—the dark side of neutrophils

OE Sørensen, N Borregaard - The Journal of clinical …, 2016 - Am Soc Clin Investig
Neutrophil extracellular traps (NETs) were discovered as extracellular strands of
decondensed DNA in complex with histones and granule proteins, which were expelled …