Synapses enable neurons to communicate with each other and are therefore a prerequisite
for normal brain function. Presynaptically, this communication requires energy and …

Eukaryotic cells have been confronted throughout their evolution with potentially lethal
plasma membrane injuries, including those caused by osmotic stress, by infection from …

▪ Abstract Correlated spiking of pre-and postsynaptic neurons can result in strengthening or
weakening of synapses, depending on the temporal order of spiking. Recent findings …

Energy use, mainly to reverse ion movements in neurons, is a fundamental constraint on
brain information processing. Trafficking of mitochondria to locations in neurons where there …

Fertilization calcium waves are introduced, and the evidence from which we can infer
general mechanisms of these waves is presented. The two main classes of hypotheses put …

Abstract The small GTPase Rab5 regulates membrane docking and fusion in the early
endocytic pathway. Here we reveal a new role for Rab5 in the regulation of endosome …

Plasma membrane integrity is essential for cellular homeostasis. In vivo, cells experience
plasma membrane damage from a multitude of stressors in the extra-and intra-cellular …

▪ Abstract Many metazoan cells inhabit mechanically stressful environments and,
consequently, their plasma membranes are frequently disrupted. Survival requires that the …

The online version of this article contains supplemental material. Address correspondence
to Sanford M. Simon, Laboratory of Cellular Biophysics, Rockefeller University, Box 304 …

Neurons form distinctive axonal and dendritic compartments that are important for directional
signaling, but the mechanisms that discriminate between axons and dendrites remain …