Targeting strategies for tissue-specific drug delivery
Off-target effects of systemically administered drugs have been a major hurdle in designing
therapies with desired efficacy and acceptable toxicity. Develo** targeting strategies to …
therapies with desired efficacy and acceptable toxicity. Develo** targeting strategies to …
Advances in drug delivery systems based on red blood cells and their membrane-derived nanoparticles
Red blood cells (RBCs) and RBC membrane-derived nanoparticles have been historically
developed as bioinspired drug delivery systems to combat the issues of premature …
developed as bioinspired drug delivery systems to combat the issues of premature …
Engineering cells for precision drug delivery: New advances, clinical translation, and emerging strategies
Cells have emerged as a promising new form of drug delivery carriers owing to their
distinguished advantages such as naturally bypassing immune recognition, intrinsic …
distinguished advantages such as naturally bypassing immune recognition, intrinsic …
Covalent conjugation of extracellular vesicles with peptides and nanobodies for targeted therapeutic delivery
Natural extracellular vesicles (EVs) are ideal drug carriers due to their remarkable
biocompatibility. Their delivery specificity can be achieved by the conjugation of targeting …
biocompatibility. Their delivery specificity can be achieved by the conjugation of targeting …
Reprogramming mitochondrial metabolism in synovial macrophages of early osteoarthritis by a camouflaged meta‐defensome
Osteoarthritis (OA) is a low‐grade inflammatory and progressive joint disease, and its
progression is closely associated with an imbalance in M1/M2 synovial macrophages …
progression is closely associated with an imbalance in M1/M2 synovial macrophages …
Lymphoid organ-targeted nanomaterials for immunomodulation of cancer, inflammation, and beyond
Nanomaterials exhibit significant potential for stimulating immune responses, offering both
local and systemic modulation across a variety of diseases. The lymphoid organs, such as …
local and systemic modulation across a variety of diseases. The lymphoid organs, such as …
Antigen-specific therapeutic approaches for autoimmunity
P Serra, P Santamaria - Nature biotechnology, 2019 - nature.com
The main function of the immune system in health is to protect the host from infection by
microbes and parasites. Because immune responses to nonself bear the risk of unleashing …
microbes and parasites. Because immune responses to nonself bear the risk of unleashing …
Red blood cell hitchhiking: a novel approach for vascular delivery of nanocarriers
Red blood cell (RBC) hitchhiking is a method of drug delivery that can increase drug
concentration in target organs by orders of magnitude. In RBC hitchhiking, drug-loaded …
concentration in target organs by orders of magnitude. In RBC hitchhiking, drug-loaded …
The role of protein corona on nanodrugs for organ-targeting and its prospects of application
S Wang, J Zhang, H Zhou, YC Lu, X **, L Luo… - Journal of Controlled …, 2023 - Elsevier
Nowadays, nanodrugs become a hotspot in the high-end medical field. They have the ability
to deliver drugs to reach their destination more effectively due to their unique properties and …
to deliver drugs to reach their destination more effectively due to their unique properties and …
Red blood cells as smart delivery systems
Red blood cells (RBCs), also called erythrocytes, are the most abundant type of blood cells.
Recently, RBCs have been extensively studied as drug delivery systems because of their …
Recently, RBCs have been extensively studied as drug delivery systems because of their …