RNA tailing, or the addition of non-templated nucleotides to the 3′ end of RNA, is the most
frequent and conserved type of RNA modification. The addition of tails and their composition …

RNA-binding proteins (RBPs) are essential for the development and function of the immune
system. They interact dynamically with RNA to control its biogenesis and turnover by …

RNA tails play integral roles in the regulation of messenger RNA (mRNA) translation and
decay. Guanylation of the poly (A) tail was discovered recently, yet the enzymology and …

The number of sequenced viral genomes has surged recently, presenting an opportunity to
understand viral diversity and uncover unknown regulatory mechanisms. Here, we …

Abstract The 3′‐end poly (A) tail is an important and potent feature of most mRNA
molecules that affects mRNA fate and translation efficiency. Polyadenylation is a …

Translation of 5′ terminal oligopyrimidine (TOP) mRNAs encoding the protein synthesis
machinery is strictly regulated by an amino-acid-sensing mTOR pathway. However, its …

Despite excellent vaccines, resurgent outbreaks of hepatitis A have caused thousands of
hospitalizations and hundreds of deaths within the United States in recent years. There is no …

In eukaryotes, almost all RNA species are processed at their 3′ ends and most mRNAs are
polyadenylated in the nucleus by canonical poly (A) polymerases. In recent years, several …

Termini often determine the fate of RNA molecules. In recent years, 3′ ends of almost all
classes of RNA species have been shown to acquire nontemplated nucleotides that are …

Hepatitis A virus (HAV) is a positive-sense RNA virus causing acute inflammation of the liver.
Here, using a genome-scale CRISPR screen, we provide a comprehensive picture of the …