Myocardial fibrosis, the expansion of the cardiac interstitium through deposition of
extracellular matrix proteins, is a common pathophysiologic companion of many different …

Fibrosis is defined as the excessive deposition of extracellular matrix (ECM) proteins in the
interstitium. It is an essential pathological response to chronic inflammation. ECM protein …

Background: Heart failure with preserved ejection fraction (HFpEF) is a growing health
problem without effective therapies. Epidemiological studies indicate that diabetes is a …

Unprecedented advances in secondary prevention have greatly improved the prognosis of
cardiovascular diseases (CVDs); however, CVDs remain a leading cause of death globally …

Although advances in preventive medicine have greatly improved prognosis, cardiovascular
disease (CVD) remains the leading cause of death worldwide. This clearly indicates that …

Cardiovascular disease (CVD) is the number one cause of death worldwide, which propels
the development of advanced technologies for CVD diagnosis and treatment. Biomarker …

Gene therapy has revolutionized the field of medicine, offering new hope for those with
common and rare diseases. For nearly three decades, adeno-associated virus (AAV) has …

Progress in precision medicine is limited by insufficient knowledge of transcriptomic or
proteomic features in involved tissues that define pathobiological differences between …

Myocardial ischemia and infarction, both in the acute and chronic phases, are associated
with cardiomyocyte loss and dramatic changes in the cardiac extracellular matrix (ECM). It …

Understanding how macrophages promote myocardial repair can help create new therapies
for infarct repair. We aimed to determine what mechanisms underlie the reparative …