The structural basis of antibody-antigen recognition
I Sela-Culang, V Kunik, Y Ofran - Frontiers in immunology, 2013 - frontiersin.org
The function of antibodies (Abs) involves specific binding to antigens (Ags) and activation of
other components of the immune system to fight pathogens. The six hypervariable loops …
other components of the immune system to fight pathogens. The six hypervariable loops …
Principles of protein-protein interactions.
S Jones, JM Thornton - Proceedings of the National …, 1996 - National Acad Sciences
This review examines protein complexes in the Brookhaven Protein Databank to gain a
better understanding of the principles governing the interactions involved in protein-protein …
better understanding of the principles governing the interactions involved in protein-protein …
Inference of macromolecular assemblies from crystalline state
E Krissinel, K Henrick - Journal of molecular biology, 2007 - Elsevier
We discuss basic physical–chemical principles underlying the formation of stable
macromolecular complexes, which in many cases are likely to be the biological units …
macromolecular complexes, which in many cases are likely to be the biological units …
The Ras-RasGAP complex: structural basis for GTPase activation and its loss in oncogenic Ras mutants
K Scheffzek, MR Ahmadian, W Kabsch, L Wiesmuller… - Science, 1997 - science.org
The three-dimensional structure of the complex between human H-Ras bound to guanosine
diphosphate and the guanosine triphosphatase (GTPase)–activating domain of the human …
diphosphate and the guanosine triphosphatase (GTPase)–activating domain of the human …
A hot spot of binding energy in a hormone-receptor interface
T Clackson, JA Wells - Science, 1995 - science.org
The x-ray crystal structure of the complex between human growth hormone (hGH) and the
extracellular domain of its first bound receptor (hGHbp) shows that about 30 side chains …
extracellular domain of its first bound receptor (hGHbp) shows that about 30 side chains …
The atomic structure of protein-protein recognition sites
LL Conte, C Chothia, J Janin - Journal of molecular biology, 1999 - Elsevier
The non-covalent assembly of proteins that fold separately is central to many biological
processes, and differs from the permanent macromolecular assembly of protein subunits in …
processes, and differs from the permanent macromolecular assembly of protein subunits in …
Shape complementarity at protein/protein interfaces
MC Lawrence, PM Colman - Journal of molecular biology, 1993 - Elsevier
A new statistic S c, which has a number of advantages over other measures of packing, is
used to examine the shape complementarity of protein/protein interfaces selected from the …
used to examine the shape complementarity of protein/protein interfaces selected from the …
Selectivity determinants of GPCR–G-protein binding
The selective coupling of G-protein-coupled receptors (GPCRs) to specific G proteins is
critical to trigger the appropriate physiological response. However, the determinants of …
critical to trigger the appropriate physiological response. However, the determinants of …
Principles of docking: An overview of search algorithms and a guide to scoring functions
The docking field has come of age. The time is ripe to present the principles of docking,
reviewing the current state of the field. Two reasons are largely responsible for the maturity …
reviewing the current state of the field. Two reasons are largely responsible for the maturity …