Shared and independent roles of CGRP and PACAP in migraine pathophysiology
A Kuburas, AF Russo - The Journal of Headache and Pain, 2023 - Springer
The neuropeptides calcitonin gene-related peptide (CGRP) and pituitary adenylate cyclase-
activating polypeptide (PACAP) have emerged as mediators of migraine pathogenesis. Both …
activating polypeptide (PACAP) have emerged as mediators of migraine pathogenesis. Both …
Tyrosine hydroxylase phosphorylation: regulation and consequences
PR Dunkley, L Bobrovskaya, ME Graham… - Journal of …, 2004 - Wiley Online Library
The rate‐limiting enzyme in catecholamine synthesis is tyrosine hydroxylase. It is
phosphorylated at serine (Ser) residues Ser8, Ser19, Ser31 and Ser40 in vitro, in situ and in …
phosphorylated at serine (Ser) residues Ser8, Ser19, Ser31 and Ser40 in vitro, in situ and in …
Immunomodulatory role of neuropeptides in the cornea
The transparency of the cornea along with its dense sensory innervation and resident
leukocyte populations make it an ideal tissue to study interactions between the nervous and …
leukocyte populations make it an ideal tissue to study interactions between the nervous and …
Pituitary adenylate cyclase activating polypeptide: a potential neuroprotective peptide
A Somogyvari-Vigh, D Reglodi - Current pharmaceutical design, 2004 - ingentaconnect.com
Pituitary adenylate cyclase activating polypeptide (PACAP) was first isolated from
hypothalamic extracts on the basis of its ability to stimulate cAMP formation in pituitary cells …
hypothalamic extracts on the basis of its ability to stimulate cAMP formation in pituitary cells …
Selenoprotein T is a PACAP‐regulated gene involved in intracellular Ca2+ mobilization and neuroendocrine secretion
Selenoproteins contain the essential trace element selenium, the deficiency of which is
associated with cancer or accelerated aging. Although selenoproteins are thought to be …
associated with cancer or accelerated aging. Although selenoproteins are thought to be …
PACAP induces light aversion in mice by an inheritable mechanism independent of CGRP
A Kuburas, BN Mason, B Hing, AS Wattiez… - Journal of …, 2021 - Soc Neuroscience
The neuropeptides CGRP (calcitonin gene-related peptide) and PACAP (pituitary adenylate
cyclase-activating polypeptide) have emerged as mediators of migraine, yet the potential …
cyclase-activating polypeptide) have emerged as mediators of migraine, yet the potential …
cAMP dose-dependently prevents palmitate-induced apoptosis by both protein kinase A-and cAMP-guanine nucleotide exchange factor-dependent pathways in β …
Lipid accumulation in pancreatic β-cells is thought to cause its dysfunction and/or
destruction via apoptosis. Our studies show that incubation of the β-cell line RINm5F with the …
destruction via apoptosis. Our studies show that incubation of the β-cell line RINm5F with the …
The neurotrophic effects of PACAP in PC12 cells: control by multiple transduction pathways
A Ravni, S Bourgault, A Lebon, P Chan… - Journal of …, 2006 - Wiley Online Library
Pituitary adenylate cyclase‐activating polypeptide (PACAP) and vasoactive intestinal
polypeptide (VIP) are closely related members of the secretin superfamily of neuropeptides …
polypeptide (VIP) are closely related members of the secretin superfamily of neuropeptides …
PACAP regulates immediate catecholamine release from adrenal chromaffin cells in an activity‐dependent manner through a protein kinase C‐dependent pathway
Adrenal medullary chromaffin cells are a major peripheral output of the sympathetic nervous
system. Catecholamine release from these cells is driven by synaptic excitation from the …
system. Catecholamine release from these cells is driven by synaptic excitation from the …
Exposure to cAMP and β‐adrenergic stimulation recruits CaV3 T‐type channels in rat chromaffin cells through Epac cAMP‐receptor proteins
M Novara, P Baldelli, D Cavallari… - The Journal of …, 2004 - Wiley Online Library
T‐type channels are expressed weakly or not at all in adult rat chromaffin cells (RCCs) and
there is contrasting evidence as to whether they play a functional role in catecholamine …
there is contrasting evidence as to whether they play a functional role in catecholamine …