FGF23 and klotho at the intersection of kidney and cardiovascular disease

D Edmonston, A Grabner, M Wolf - Nature Reviews Cardiology, 2024‏ - nature.com
Cardiovascular disease is the leading cause of death in patients with chronic kidney disease
(CKD). As CKD progresses, CKD-specific risk factors, such as disordered mineral …

Direct and indirect effects of fibroblast growth factor 23 on the heart

T Nakano, H Kishimoto, M Tokumoto - Frontiers in endocrinology, 2023‏ - frontiersin.org
Fibroblast growth factor (FGF) 23 is a bone-derived phosphotropic hormone that regulates
phosphate and mineral homeostasis. Recent studies have provided evidence that a high …

Fibroblast growth factor-23 and the risk of cardiovascular diseases and mortality in the general population: A systematic review and dose-response meta-analysis

M Liu, P **a, Z Tan, T Song, K Mei, J Wang… - Frontiers in …, 2022‏ - frontiersin.org
Background In the past decade, fibroblast growth factor 23 (FGF23) has been recognized as
an important biomarker of cardiovascular diseases. This study aimed to assess the …

[HTML][HTML] Fibroblast growth factor 23 and risk of heart failure subtype: the CRIC (Chronic Renal Insufficiency Cohort) study

AS Leidner, X Cai, LR Zelnick, J Lee, N Bansal… - Kidney Medicine, 2023‏ - Elsevier
Rationale & Objective Heart failure (HF) is an important cause of morbidity and mortality
among individuals with chronic kidney disease (CKD). A large body of evidence from …

Fibroblast growth factor 23 independently predicts adverse outcomes after an acute coronary syndrome

A Kallmeyer, A Pello, E Cánovas, Á Aceña… - ESC Heart …, 2024‏ - Wiley Online Library
Aims Abnormalities of mineral metabolism (MM) have been related to cardiovascular
disorders. There are no reports on the prognostic role of MM after an acute coronary …

Is there a role in acute kidney injury for FGF23 and Klotho?

D Mattinzoli, P Molinari… - Clinical Kidney …, 2023‏ - academic.oup.com
Cardio-renal syndrome is a clinical condition that has recently been well defined. In acute
kidney disease, this interaction might trigger chronic processes determining the onset of …

[HTML][HTML] New Biomarkers in the Prognostic Assessment of Acute Heart Failure with Reduced Ejection Fraction: Beyond Natriuretic Peptides

M Cortés, J Lumpuy-Castillo… - International Journal of …, 2025‏ - mdpi.com
Natriuretic peptides are established biomarkers related to the prognosis of heart failure. New
biomarkers have emerged in the field of cardiovascular disease. The prognostic value of …

HFpEF: New biomarkers and their diagnostic and prognostic value

S parveen Shaik, H hyder Karan, A Singh… - Current Problems in …, 2024‏ - Elsevier
Heart failure characterized by preserved ejection fraction (HFpEF) poses a substantial
challenge to healthcare systems worldwide and the diagnostic algorithms used currently …

Fibroblast growth factor 23 and outcomes of atrial fibrillation: from clinical association to genetic evidence

J Li, Y Lai, C Jiang, M Li, Z Yang, M Zhao… - European Journal of …, 2025‏ - academic.oup.com
Aims Fibroblast growth factor 23 (FGF23) has been implicated in the occurrence of atrial
fibrillation (AF), but its prognostic value in AF patients remains unclear. Methods and results …

[HTML][HTML] MCP1 Could mediate FGF23 and omega 6/omega 3 correlation inversion in CKD

D Mattinzoli, S Turolo, CM Alfieri, M Ikehata… - Journal of Clinical …, 2022‏ - mdpi.com
Fibroblast growth factor 23 (FGF23) concentrations rise after the early stages of chronic
kidney disease (CKD). FGF23 is involved in inflammatory reactions closely associated with …