Smart cancer nanomedicine

R van der Meel, E Sulheim, Y Shi, F Kiessling… - Nature …, 2019 - nature.com
Nanomedicines are extensively employed in cancer therapy. We here propose four strategic
directions to improve nanomedicine translation and exploitation.(1) Patient stratification has …

Cancer nanotechnology: current status and perspectives

JA Kemp, YJ Kwon - Nano convergence, 2021 - Springer
Modern medicine has been waging a war on cancer for nearly a century with no tangible
end in sight. Cancer treatments have significantly progressed, but the need to increase …

Nanotechnology for COVID-19: therapeutics and vaccine research

G Chauhan, MJ Madou, S Kalra, V Chopra, D Ghosh… - ACS …, 2020 - ACS Publications
The current global health threat by the novel coronavirus disease 2019 (COVID-19) requires
an urgent deployment of advanced therapeutic options available. The role of …

A systematic strategy of combinational blow for overcoming cascade drug resistance via NIR‐light‐triggered hyperthermia

L Wang, Y Yu, D Wei, L Zhang, X Zhang… - Advanced …, 2021 - Wiley Online Library
A systematic combination strategy is proposed for overcoming cisplatin resistance using
near‐infrared (NIR)‐light‐triggered hyperthermia. A new photothermal polymer DAP‐F is …

[HTML][HTML] Recent advances in nanocarrier-assisted therapeutics delivery systems

S Su, PM Kang - Pharmaceutics, 2020 - mdpi.com
Nanotechnologies have attracted increasing attention in their application in medicine,
especially in the development of new drug delivery systems. With the help of nano-sized …

Engineering self-assembling protein nanoparticles for therapeutic delivery

A Olshefsky, C Richardson, SH Pun… - Bioconjugate …, 2022 - ACS Publications
Despite remarkable advances over the past several decades, many therapeutic
nanomaterials fail to overcome major in vivo delivery barriers. Controlling immunogenicity …

Overview and update on methods for cargo loading into extracellular vesicles

Y Han, TW Jones, S Dutta, Y Zhu, X Wang… - Processes, 2021 - mdpi.com
The enormous library of pharmaceutical compounds presents endless research avenues.
However, several factors limit the therapeutic potential of these drugs, such as drug …

The primary mechanism of cytotoxicity of the chemotherapeutic agent CX-5461 is topoisomerase II poisoning

PM Bruno, M Lu, KA Dennis, H Inam, CJ Moore… - Proceedings of the …, 2020 - pnas.org
Small molecules can affect many cellular processes. The disambiguation of these effects to
identify the causative mechanisms of cell death is extremely challenging. This challenge …

Platinum (iv) prodrugs with long lipid chains for drug delivery and overcoming cisplatin resistance

Q Chen, Y Yang, X Lin, W Ma, G Chen, W Li… - Chemical …, 2018 - pubs.rsc.org
Platinum( iv ) prodrugs with long lipid chains for drug delivery and overcoming cisplatin
resistance - Chemical Communications (RSC Publishing) DOI:10.1039/C8CC02791A Royal …

Glutathione‐Responsive Nanoparticles of Camptothecin Prodrug for Cancer Therapy

L Zhang, L Zhu, L Tang, J **e, Y Gao, C Yu… - Advanced …, 2023 - Wiley Online Library
Camptothecin (CPT) is a potent chemotherapeutic agent for various cancers, but the broader
application of CPT is still hindered by its poor bioavailability and systemic toxicity. Here, a …