Apelin is an endogenous peptide identified as a ligand of the G protein-coupled receptor
APJ. Apelin belongs to the family of adipokines, which are bioactive mediators released by …

Apelin is a natural ligand for the G protein-coupled receptor APJ, and the apelin/APJ system
is widely distributed in vivo. Among the apelin family, apelin-13 is the major apelin isoform in …

Apelin is a peptide originally isolated from bovine stomach tissue extracts and identified as
an endogenous ligand of the APJ receptor; recent work showed that apelin ameliorates the …

Apelin, an endogenous ligand for the G protein-coupled receptor APJ, is extensively
expressed in various systems, especially the nervous system. This article reviews the role of …

Cerebral ischemia/reperfusion (I/R) injury-induced neuronal apoptosis contributes to the
death and disability in patients with ischemic stroke. However, underlying mechanisms …

Vascular disease is a common problem with high mortality all over the world. Apelin-13, a
key subtype of apelin, takes part in many physiological and pathological responses via …

Apelin, an endogenous neuropeptide, has been identified as the cognate ligand for the G-
protein-coupled receptor APJ. Apelin, APJ messenger RNA, and protein are widely …

Apelin, an endogenous ligand for the G protein-coupled receptor APJ, is widely expressed
in various organs. Recent research has indicated that the Apelin/APJ system plays an …

Neurodegenerative diseases, including Alzheimer's disease (AD), Parkinson's disease (PD),
and Huntington's disease (HD), are incurable diseases characterized by progressive loss of …

It is well-established that reperfusion following cerebral ischemic injury gives rise to
secondary injury accompanied by structural and functional damage. However, it remains …