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Targeting the tumor stroma for cancer therapy
M Xu, T Zhang, R **a, Y Wei, X Wei - Molecular Cancer, 2022 - Springer
Tumors are comprised of both cancer cells and surrounding stromal components. As an
essential part of the tumor microenvironment, the tumor stroma is highly dynamic …
essential part of the tumor microenvironment, the tumor stroma is highly dynamic …
Challenges and advances in clinical applications of mesenchymal stromal cells
Mesenchymal stromal cells (MSCs), also known as mesenchymal stem cells, have been
intensely investigated for clinical applications within the last decades. However, the majority …
intensely investigated for clinical applications within the last decades. However, the majority …
Exploring the dynamic interplay between cancer stem cells and the tumor microenvironment: implications for novel therapeutic strategies
Cancer stem cells (CSCs) have emerged as key contributors to tumor initiation, growth, and
metastasis. In addition, CSCs play a significant role in inducing immune evasion, thereby …
metastasis. In addition, CSCs play a significant role in inducing immune evasion, thereby …
Current and future immunotherapeutic approaches in pancreatic cancer treatment
Pancreatic cancer is a major cause of cancer-related death, but despondently, the outlook
and prognosis for this resistant type of tumor have remained grim for a long time. Currently, it …
and prognosis for this resistant type of tumor have remained grim for a long time. Currently, it …
Epithelial and stromal co-evolution and complicity in pancreatic cancer
SR Hingorani - Nature Reviews Cancer, 2023 - nature.com
Pancreatic ductal adenocarcinomas are distinguished by their robust desmoplasia, or
fibroinflammatory response. Dominated by non-malignant cells, the mutated epithelium must …
fibroinflammatory response. Dominated by non-malignant cells, the mutated epithelium must …
Novel strategies for cancer immunotherapy: counter-immunoediting therapy
S Liu, Q Sun, X Ren - Journal of Hematology & Oncology, 2023 - Springer
The advent of immunotherapy has made an indelible mark on the field of cancer therapy,
especially the application of immune checkpoint inhibitors in clinical practice. Although …
especially the application of immune checkpoint inhibitors in clinical practice. Although …
The LIN28/let-7 pathway in cancer
Among all tumor suppressor microRNAs, reduced let-7 expression occurs most frequently in
cancer and typically correlates with poor prognosis. Activation of either LIN28A or LIN28B …
cancer and typically correlates with poor prognosis. Activation of either LIN28A or LIN28B …
The role of stromal cancer-associated fibroblasts in pancreatic cancer
Pancreatic ductal adenocarcinoma (PDAC) is a lethal cancer generally refractory to
conventional treatments. Cancer-associated fibroblasts (CAFs) are cellular components of …
conventional treatments. Cancer-associated fibroblasts (CAFs) are cellular components of …
Tumour-associated mesenchymal stem/stromal cells: emerging therapeutic targets
Mesenchymal stem cells, also known as mesenchymal stromal cells (MSCs), exist in many
tissues and are known to actively migrate to sites of tissue injury, where they participate in …
tissues and are known to actively migrate to sites of tissue injury, where they participate in …
[HTML][HTML] Taxol-loaded MSC-derived exosomes provide a therapeutic vehicle to target metastatic breast cancer and other carcinoma cells
MSC-derived exosomes display, among others, an efficient biocompatibility and a reduced
intrinsic immunogenicity, representing a valuable vehicle for drug delivery in a tumor …
intrinsic immunogenicity, representing a valuable vehicle for drug delivery in a tumor …