Cyclic dinucleotides (CDNs) are highly versatile signalling molecules that control various
important biological processes in bacteria. The best-studied example is cyclic di-GMP (c-di …

Biofilm formation and biofilm-induced biodeterioration of surfaces have deeply affected the
life of our community. Cyclic dimeric guanosine monophosphate (c-di-GMP) is a small …

Objectives Antimicrobial resistance (AMR) in clinically relevant bacteria is a growing threat
to public health globally. In these bacteria, antimicrobial resistance genes are often …

The striking multiplicity, signal input diversity, and output specificity of c-di-GMP signaling
proteins in many bacteria has brought second messenger signaling back onto the agenda of …

Bacteriophages (phages) are critical players in the dynamics and function of microbial
communities and drive processes as diverse as global biogeochemical cycles and human …

The bacterial second messenger bis-(3′-5′)-cyclic diguanosine monophosphate (c-di-
GMP) ubiquitously promotes bacterial biofilm formation. Intracellular pools of c-di-GMP seem …

Accurate measurements of cellular protein concentrations are invaluable to quantitative
studies of gene expression and physiology in living cells. Here, we developed a versatile …

Background Bovine mastitis is the most common infectious disease in dairy cattle with major
economic implications for the dairy industry worldwide. Continuous monitoring for the …

Bacterial biofilms are an ever‐growing concern for public health, featuring both inherited
genetic resistance and a conferred innate tolerance to traditional antibiotic therapies …

The bacterial second messenger c-di-GMP controls bacterial biofilm formation, motility, cell
cycle progression, development and virulence. It is synthesized by diguanylate cyclases …