This paper reviews the mathematical basis of maximum likelihood. The likelihood function
for macromolecular structures is extended to include prior phase information and …

In the past few years, many exciting papers reported results based on crystal structure
determination by electron diffraction. The aim of this review is to provide general and …

The Collaborative Computational Project No. 4 (CCP4) is a UK-led international collective
with a mission to develop, test, distribute and promote software for macromolecular …

The pandemic caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-
2) continues to expand. Papain-like protease (PLpro) is one of two SARS-CoV-2 proteases …

Abstract Severe Acute Respiratory Syndrome coronavirus 2 (SARS‐CoV‐2) is rapidly
spreading around the world. There is no existing vaccine or proven drug to prevent …

Papain-like protease (PLpro) is an attractive drug target for SARS-CoV-2 because it is
essential for viral replication, cleaving viral poly-proteins pp1a and pp1ab, and has de …

Following integration of the observed diffraction spots, the process ofdata reduction'initially
aims to determine the point-group symmetry of the data and the likely space group. This can …

phenix. refine is a program within the PHENIX package that supports crystallographic
structure refinement against experimental data with a wide range of upper resolution limits …

Cells use compartmentalization of enzymes as a strategy to regulate metabolic pathways
and increase their efficiency. The α-and β-carboxysomes of cyanobacteria contain ribulose …

Substantial improvements in enzyme activity demand multiple mutations at spatially
proximal positions in the active site. Such mutations, however, often exhibit unpredictable …