Biomolecules are in constant motion. To understand how they function, and why
malfunctions can cause disease, it is necessary to describe their three-dimensional …

Cells respond to protein-damaging (proteotoxic) stress by activation of the Heat Shock
Response (HSR). The HSR provides cells with an enhanced ability to endure proteotoxic …

While acetylated, RNA-binding-deficient TDP-43 reversibly phase separates within nuclei
into complex droplets (anisosomes) comprised of TDP-43-containing liquid outer shells and …

Misfolding, aggregation, and aberrant accumulation of proteins are central components in
the progression of neurodegenerative disease. Cellular molecular chaperone systems …

A major role for the intracellular post-translational modification O-GlcNAc appears to be the
inhibition of protein aggregation. Most of the previous studies in this area focused on O …

Highlights•Sparsely populated protein states can play significant biological roles.•NMR
spectroscopy can structurally and dynamically characterize 'invisible'protein states.•We …

The family of the human small Heat Shock Proteins (HSPBs) consists of ten members of
chaperones (HSPB1-HSPB10), characterized by a low molecular weight and capable of …

Resistance to therapy is a major obstacle to cancer treatment. It may exist from the
beginning, or it may develop during therapy. The review focusses on oncolytic Newcastle …

Small heat shock proteins are ubiquitously expressed chaperones, yet mutations in some of
them cause tissue-specific diseases. Here, we will discuss how small heat shock proteins …

Neurodegenerative diseases such as Alzheimer's and Parkinson's remain highly prevalent
and incurable disorders. A major challenge in fully understanding and combating the …