Structural and quantitative chromosomal rearrangements, collectively referred to as
structural variation (SV), contribute to a large extent to the genetic diversity of the human …

A class of cis-regulatory elements, called enhancers, play a central role in orchestrating
spatiotemporally precise gene-expression programs during development. Consequently …

We have known for decades that long noncoding RNAs (lncRNAs) can play essential
functions across most forms of life. The maintenance of chromosome length requires an …

The idea that epigenetic determinants such as DNA methylation, histone modifications or
RNA can be passed to the next generation through meiotic products (gametes) is long …

Genome-wide sequencing has led to the discovery of thousands of long non-coding RNA
(lncRNA) loci in the human genome, but evidence of functional significance has remained …

Discoveries over the past decade portend a paradigm shift in molecular biology. Evidence
suggests that RNA is not only functional as a messenger between DNA and protein but also …

Cis-regulatory elements (CREs) control gene expression, orchestrating tissue identity,
developmental timing and stimulus responses, which collectively define the thousands of …

Long-range regulatory interactions play an important role in sha** gene-expression
programs. However, the genomic features that organize these activities are still poorly …

Chromatin consists of a complex of DNA and histone proteins as its core components and
plays an important role in both packaging DNA and regulating DNA metabolic pathways …

The activity of the glucocorticoid receptor (GR), a nuclear receptor transcription factor
belonging to subclass 3C of the steroid/thyroid hormone receptor superfamily, is typically …