Adenylyl cyclase isoforms 5 and 6 in the cardiovascular system: complex regulation and divergent roles

S Maghsoudi, R Shuaib, B Van Bastelaere… - Frontiers in …, 2024 - frontiersin.org
Adenylyl cyclases (ACs) are crucial effector enzymes that transduce divergent signals from
upstream receptor pathways and are responsible for catalyzing the conversion of ATP to …

Adenylyl cyclase isoform 6 in the pulmonary artery is inhibited by hypoxia via cysteine nitrosylation

S Maghsoudi, V Bhatia, M Hinton, N Singh… - American Journal of …, 2025 - atsjournals.org
Persistent pulmonary hypertension of the newborn (PPHN) is a hypoxic disorder of
pulmonary vascular relaxation, mediated in part by adenylyl cyclase (AC). Neonatal …

Platelet inhibition by hypochlorous acid involves cAMP signalling

L O'Donoghue, D Hiebner, R Krishnankutty, I Schoen… - Cellular …, 2025 - Elsevier
Hypochlorous acid (HOCl), made by neutrophil-derived myeloperoxidase, has been
suggested to inhibit platelets, however, the mechanisms involved have not been described …

[HTML][HTML] Repeated-Dose Toxicity of Lauric Acid and Its Preventive Effect Against Tracheal Hyper-Responsiveness in Wistar Rats with Possible In Silico Molecular …

IAD Figueiredo, AMO Martins, AMT Cavalcanti… - Pharmaceuticals, 2025 - mdpi.com
Background/Objectives: Lauric acid (LA), a medium-chain fatty acid, is a promising drug for
asthma treatment. This study evaluated the toxicity of repeated doses and the effect of LA on …