Cardiometabolic diseases (CMD) are a direct consequence of modern living and contribute
to the development of multisystem diseases such as cardiovascular diseases and diabetes …

Cardiac remodeling occurs after cardiac pressure/volume overload or myocardial injury
during the development of heart failure and is a determinant of heart failure. Preventing or …

The present study designed to investigate the protective effect of curcumin nanoparticles
(CUR-NPs) on the cardiotoxicity induced by doxorubicin. Rats were divided into four groups; …

Technological advances have made genetically modified mice, including transgenic and
gene knockout mice, an essential tool in many research fields. Adult cardiomyocytes are …

Exposure of intact cells to selective inhibitors of Na+/K+-ATPase such as ouabain activates
several growth-related cell signaling pathways. It has been suggested that the initial event of …

The Na/K-ATPase is an important membrane ion transporter and a signaling receptor that is
essential for maintaining normal cell function. The current study examined the role of Na/K …

Ouabain is of cardiotonic steroids (CTS) family that is plant-derived compounds and is
known for many years as therapeutic and cytotoxic agents. They are specific inhibitors of Na …

Cell cycle regulation through the manipulation of endogenous membrane potentials offers
tremendous opportunities to control cellular processes during tissue repair and cancer …

Background Experimental uremic cardiomyopathy causes cardiac fibrosis and is causally
related to the increased circulating levels of the cardiotonic steroid, marinobufagenin (MBG) …

Steroid hormones regulate cell function via specific receptors, members of a super family of
ligand activated transcription factors, expressed in their target tissues. A second oestrogen …