Enhancer function: new insights into the regulation of tissue-specific gene expression
Enhancer function underlies regulatory processes by which cells establish patterns of gene
expression. Recent results suggest that many enhancers are specified by particular …
expression. Recent results suggest that many enhancers are specified by particular …
Long-range chromatin interactions
To accommodate genomes in the limited space of the cell nucleus and ensure the correct
execution of gene expression programs, genomes are packaged in complex fashion in the …
execution of gene expression programs, genomes are packaged in complex fashion in the …
Parallel analysis of transcription, integration, and sequence of single HIV-1 proviruses
HIV-1-infected cells that persist despite antiretroviral therapy (ART) are frequently
considered" transcriptionally silent," but active viral gene expression may occur in some …
considered" transcriptionally silent," but active viral gene expression may occur in some …
A high-resolution map of the three-dimensional chromatin interactome in human cells
A large number of cis-regulatory sequences have been annotated in the human genome,,
but defining their target genes remains a challenge. One strategy is to identify the long …
but defining their target genes remains a challenge. One strategy is to identify the long …
H3K27me3-rich genomic regions can function as silencers to repress gene expression via chromatin interactions
The mechanisms underlying gene repression and silencers are poorly understood. Here we
investigate the hypothesis that H3K27me3-rich regions of the genome, defined from clusters …
investigate the hypothesis that H3K27me3-rich regions of the genome, defined from clusters …
[HTML][HTML] Controlling long-range genomic interactions at a native locus by targeted tethering of a loo** factor
Chromatin loops juxtapose distal enhancers with active promoters, but their molecular
architecture and relationship with transcription remain unclear. In erythroid cells, the locus …
architecture and relationship with transcription remain unclear. In erythroid cells, the locus …
Genome-wide map of regulatory interactions in the human genome
N Heidari, DH Phanstiel, C He, F Grubert… - Genome …, 2014 - genome.cshlp.org
Increasing evidence suggests that interactions between regulatory genomic elements play
an important role in regulating gene expression. We generated a genome-wide interaction …
an important role in regulating gene expression. We generated a genome-wide interaction …
Wheat chromatin architecture is organized in genome territories and transcription factories
L Concia, A Veluchamy, JS Ramirez-Prado… - Genome Biology, 2020 - Springer
Background Polyploidy is ubiquitous in eukaryotic plant and fungal lineages, and it leads to
the co-existence of several copies of similar or related genomes in one nucleus. In plants …
the co-existence of several copies of similar or related genomes in one nucleus. In plants …
Capture Hi-C reveals novel candidate genes and complex long-range interactions with related autoimmune risk loci
P Martin, A McGovern, G Orozco, K Duffus… - Nature …, 2015 - nature.com
Genome-wide association studies have been tremendously successful in identifying genetic
variants associated with complex diseases. The majority of association signals are …
variants associated with complex diseases. The majority of association signals are …
Transcription factories: genome organization and gene regulation
A Papantonis, PR Cook - Chemical reviews, 2013 - ACS Publications
All eukaryotic cells contain four RNA polymerases originally defined by their sensitivity to
different drugs, and now by the sets of genes they transcribe. 1− 4 Polymerase I produces …
different drugs, and now by the sets of genes they transcribe. 1− 4 Polymerase I produces …