TET (Ten-eleven translocation) family proteins: structure, biological functions and applications
X Zhang, Y Zhang, C Wang, X Wang - Signal Transduction and …, 2023 - nature.com
Ten-eleven translocation (TET) family proteins (TETs), specifically, TET1, TET2 and TET3,
can modify DNA by oxidizing 5-methylcytosine (5mC) iteratively to yield 5 …
can modify DNA by oxidizing 5-methylcytosine (5mC) iteratively to yield 5 …
Targeting the epigenome to reinvigorate T cells for cancer immunotherapy
D **ong, L Zhang, ZJ Sun - Military Medical Research, 2023 - Springer
Cancer immunotherapy using immune-checkpoint inhibitors (ICIs) has revolutionized the
field of cancer treatment; however, ICI efficacy is constrained by progressive dysfunction of …
field of cancer treatment; however, ICI efficacy is constrained by progressive dysfunction of …
Identification and transcriptome analysis of erythroblastic island macrophages
W Li, Y Wang, H Zhao, H Zhang, Y Xu… - Blood, The Journal …, 2019 - ashpublications.org
The erythroblastic island (EBI), composed of a central macrophage and surrounding
erythroid cells, was the first hematopoietic niche discovered. The identity of EBI …
erythroid cells, was the first hematopoietic niche discovered. The identity of EBI …
TET3 promotes AML growth and epigenetically regulates glucose metabolism and leukemic stem cell associated pathways
AJ Pulikkottil, S Bamezai, T Ammer, F Mohr, K Feder… - Leukemia, 2022 - nature.com
Acute myeloid leukemia (AML) is considered a poor prognosis malignancy where patients
exhibit altered glucose metabolism and stem cell signatures that contribute to AML growth …
exhibit altered glucose metabolism and stem cell signatures that contribute to AML growth …
TET2 modulates spatial relocalization of heterochromatin in aged hematopoietic stem and progenitor cells
DNA methylation deregulation at partially methylated domains (PMDs) represents an
epigenetic signature of aging and cancer, yet the underlying molecular basis and resulting …
epigenetic signature of aging and cancer, yet the underlying molecular basis and resulting …
Impairment of human terminal erythroid differentiation by histone deacetylase 5 deficiency
Histone deacetylases (HDACs) are a group of enzymes that catalyze the removal of acetyl
groups from histone and nonhistone proteins. HDACs have been shown to have diverse …
groups from histone and nonhistone proteins. HDACs have been shown to have diverse …
Role of TET dioxygenases in the regulation of both normal and pathological hematopoiesis
The family of ten-eleven translocation dioxygenases (TETs) consists of TET1, TET2, and
TET3. Although all TETs are expressed in hematopoietic tissues, only TET2 is commonly …
TET3. Although all TETs are expressed in hematopoietic tissues, only TET2 is commonly …
TET2 mutation as prototypic clonal hematopoiesis lesion
L Guarnera, BK Jha - Seminars in Hematology, 2024 - Elsevier
Loss of function TET2 mutation (TET2 MT) is one of the most frequently observed lesions in
clonal haematopoiesis (CH). TET2 a member TET-dioxygenase family of enzyme that along …
clonal haematopoiesis (CH). TET2 a member TET-dioxygenase family of enzyme that along …
Erythroblastic island macrophages shape normal erythropoiesis and drive associated disorders in erythroid hematopoietic diseases
W Li, R Guo, Y Song, Z Jiang - Frontiers in Cell and Developmental …, 2021 - frontiersin.org
Erythroblastic islands (EBIs), discovered more than 60 years ago, are specialized
microenvironments for erythropoiesis. This island consists of a central macrophage with …
microenvironments for erythropoiesis. This island consists of a central macrophage with …
Putative regulators for the continuum of erythroid differentiation revealed by single-cell transcriptome of human BM and UCB cells
P Huang, Y Zhao, J Zhong, X Zhang… - Proceedings of the …, 2020 - National Acad Sciences
Fine-resolution differentiation trajectories of adult human hematopoietic stem cells (HSCs)
involved in the generation of red cells is critical for understanding dynamic developmental …
involved in the generation of red cells is critical for understanding dynamic developmental …