Motor neurons and the generation of spinal motor neuron diversity
Motor neurons (MNs) are neuronal cells located in the central nervous system (CNS)
controlling a variety of downstream targets. This function infers the existence of MN subtypes …
controlling a variety of downstream targets. This function infers the existence of MN subtypes …
Therapeutic targeting of EPH receptors and their ligands
Critical roles for EPH receptor (EPH)–ephrin signalling in a range of chronic and
regenerative diseases are increasingly being recognized. In particular, the complex roles of …
regenerative diseases are increasingly being recognized. In particular, the complex roles of …
Getting neural circuits into shape with semaphorins
Semaphorins are key players in the control of neural circuit development. Recent studies
have uncovered several exciting and novel aspects of neuronal semaphorin signalling in …
have uncovered several exciting and novel aspects of neuronal semaphorin signalling in …
Pathway and network-based analysis of genome-wide association studies in multiple sclerosis
Genome-wide association studies (GWAS) testing several hundred thousand SNPs have
been performed in multiple sclerosis (MS) and other complex diseases. Typically, the …
been performed in multiple sclerosis (MS) and other complex diseases. Typically, the …
Cellular strategies of axonal pathfinding
J Raper, C Mason - Cold Spring Harbor perspectives in …, 2010 - cshperspectives.cshlp.org
Axons follow highly stereotyped and reproducible trajectories to their targets. In this review
we address the properties of the first pioneer neurons to grow in the develo** nervous …
we address the properties of the first pioneer neurons to grow in the develo** nervous …
Pre-target axon sorting establishes the neural map topography
Sensory information detected by the peripheral nervous system is represented as a
topographic map in the brain. It has long been thought that the topography of the map is …
topographic map in the brain. It has long been thought that the topography of the map is …
[HTML][HTML] Ret is a multifunctional coreceptor that integrates diffusible-and contact-axon guidance signals
Growing axons encounter multiple guidance cues, but it is unclear how separate signals are
resolved and integrated into coherent instructions for growth cone navigation. We report that …
resolved and integrated into coherent instructions for growth cone navigation. We report that …
Motor axon pathfinding
Motor neurons are functionally related, but represent a diverse collection of cells that show
strict preferences for specific axon pathways during embryonic development. In this article …
strict preferences for specific axon pathways during embryonic development. In this article …
Ephrin-mediated cis-attenuation of Eph receptor signaling is essential for spinal motor axon guidance
Axon guidance receptors guide neuronal growth cones by binding in trans to axon guidance
ligands in the develo** nervous system. Some ligands are coexpressed in cis with their …
ligands in the develo** nervous system. Some ligands are coexpressed in cis with their …
Molecular identity of proprioceptor subtypes innervating different muscle groups in mice
The precise execution of coordinated movements depends on proprioception, the sense of
body position in space. However, the molecular underpinnings of proprioceptive neuron …
body position in space. However, the molecular underpinnings of proprioceptive neuron …