The biofilm matrix: multitasking in a shared space

HC Flemming, ED van Hullebusch, TR Neu… - Nature Reviews …, 2023 - nature.com
The biofilm matrix can be considered to be a shared space for the encased microbial cells,
comprising a wide variety of extracellular polymeric substances (EPS), such as …

Plasmid transfer by conjugation in Gram-negative bacteria: from the cellular to the community level

C Virolle, K Goldlust, S Djermoun, S Bigot, C Lesterlin - Genes, 2020 - mdpi.com
Bacterial conjugation, also referred to as bacterial sex, is a major horizontal gene transfer
mechanism through which DNA is transferred from a donor to a recipient bacterium by direct …

Current challenges and future opportunities of phage therapy

DP Pires, AR Costa, G Pinto, L Meneses… - FEMS microbiology …, 2020 - academic.oup.com
Antibiotic resistance is a major public health challenge worldwide, whose implications for
global health might be devastating if novel antibacterial strategies are not quickly …

Mechanisms Underlying Vibrio cholerae Biofilm Formation and Dispersion

JK Teschler, CD Nadell, K Drescher… - Annual Review of …, 2022 - annualreviews.org
Biofilms are a widely observed growth mode in which microbial communities are spatially
structured and embedded in a polymeric extracellular matrix. Here, we focus on the model …

Development of antibiofilm therapeutics strategies to overcome antimicrobial drug resistance

S Nadar, T Khan, SG Patching, A Omri - Microorganisms, 2022 - mdpi.com
A biofilm is a community of stable microorganisms encapsulated in an extracellular matrix
produced by themselves. Many types of microorganisms that are found on living hosts or in …

Secondary effects of antibiotics on microbial biofilms

A Penesyan, IT Paulsen, MR Gillings… - Frontiers in …, 2020 - frontiersin.org
Biofilms are assemblages of microorganisms attached to each other, or to a surface, and
encased in a protective, self-produced matrix. Such associations are now recognized as the …

Short-range quorum sensing controls horizontal gene transfer at micron scale in bacterial communities

J van Gestel, T Bareia, B Tenennbaum… - Nature …, 2021 - nature.com
In bacterial communities, cells often communicate by the release and detection of small
diffusible molecules, a process termed quorum-sensing. Signal molecules are thought to …

Biofilm formation on human immune cells is a multicellular predation strategy of Vibrio cholerae

L Vidakovic, S Mikhaleva, H Jeckel, V Nisnevich… - Cell, 2023 - cell.com
Biofilm formation is generally recognized as a bacterial defense mechanism against
environmental threats, including antibiotics, bacteriophages, and leukocytes of the human …

Antibiotic resistance in bacterial communities

M Denk-Lobnig, KB Wood - Current opinion in microbiology, 2023 - Elsevier
Bacteria are single-celled organisms, but the survival of microbial communities relies on
complex dynamics at the molecular, cellular, and ecosystem scales. Antibiotic resistance, in …

Advances and opportunities in image analysis of bacterial cells and communities

H Jeckel, K Drescher - FEMS Microbiology Reviews, 2021 - academic.oup.com
The cellular morphology and sub-cellular spatial structure critically influence the function of
microbial cells. Similarly, the spatial arrangement of genotypes and phenotypes in microbial …