This Review aims to summarize advances over the last 15 years in the development of
active pharmaceutical ingredient ionic liquids (API-ILs), which make up a prospective game …

Ionic liquids (ILs) play a crucial role in the design of novel materials. The ionic nature of ILs
provides numerous advantages in drug delivery, acting as a green solvent or active …

In the drug delivery system, the transdermal drug delivery system has the advantages of
painless administration, avoiding the first-pass metabolism, sustained therapeutic effect, and …

The development of effective drug formulations and delivery systems for newly developed or
marketed drug molecules remains a significant challenge. These drugs can exhibit …

Highlights•Ionic liquids (ILs) are ions-based substances with melting points below 100
C.•Versatile nature and properties of ILs made it as solvent and designer …

The transdermal delivery of hydrophilic drugs remains challenging owing to their poor ability
to permeate the skin; formulation with oil media is difficult without adding chemical …

Highlights•ILs, a potential approach for improving physico-chemical and biological
properties of APIs.•Mucus membranes serves as a barrier for drug delivery.•Choline-based …

Ionic liquids are a very important class of molecules being used in a wide range of
applications. Recently, ionic liquids have been tested as anti-cancer agents and found …

Ionic liquids (ILs) have been in utility since the beginning of the 1980s due to their vast
range of features, uses, and environmentally acceptable nature. They have been presented …

Cancer is one of the most life-threatening family of diseases that cause death worldwide. As
a highly researched and successful therapeutic agent, methotrexate (MTX) treats many solid …