Natural products with antischistosomal activity

J de Moraes - Future Medicinal Chemistry, 2015 - Taylor & Francis
In recent years, natural product groups have been gaining prominence as possible sources
of new drugs for schistosomiasis. This review attempts to update the antischistosomal …

Computational quantum chemistry, molecular docking, and ADMET predictions of imidazole alkaloids of Pilocarpus microphyllus with schistosomicidal properties

JA Rocha, NCS Rego, BTS Carvalho, FI Silva… - PloS one, 2018 - journals.plos.org
Schistosomiasis affects million people and its control is widely dependent on a single drug,
praziquantel. Computational chemistry has led to the development of new tools that predict …

Anthelmintic Activity In Vivo of Epiisopiloturine against Juvenile and Adult Worms of Schistosoma mansoni

MA Guimaraes, RN de Oliveira… - PLoS neglected …, 2015 - journals.plos.org
Schistosomiasis is a serious disease currently estimated to affect more that 207 million
people worldwide. Due to the intensive use of praziquantel, there is increasing concern …

Lycopene-rich extract from red guava (Psidium guajava L.) displays cytotoxic effect against human breast adenocarcinoma cell line MCF-7 via an apoptotic-like …

RC Dos Santos, AS Ombredane, JMT Souza… - Food Research …, 2018 - Elsevier
This study investigated a lycopene-rich extract from red guava (LEG) for its chemical
composition using spectrophotometry, mass spectrometry, attenuated total reflectance …

Anthelmintic, Antibacterial and Cytotoxicity Activity of Imidazole Alkaloids from Pilocarpus microphyllus Leaves

JA Rocha, IM Andrade, LMC Véras… - Phytotherapy …, 2017 - Wiley Online Library
Pilocarpus microphyllus Stapf ex Wardlew (Rutaceae), popularly known as jaborandi, is a
plant native to the northern and northeastern macroregions of Brazil. Several alkaloids from …

Epiisopilosine alkaloid has activity against Schistosoma mansoni in mice without acute toxicity

MA Guimarães, RN de Oliveira, RL de Almeida… - PLoS …, 2018 - journals.plos.org
Schistosomiasis is a disease caused by parasites of the genus Schistosoma, currently
affecting more than 200 million people. Among the various species of this parasite that infect …

Acetylated cashew gum-based nanoparticles for the incorporation of alkaloid epiisopiloturine

J do Amaral Rodrigues, AR de Araújo… - International journal of …, 2019 - Elsevier
The natural alkaloid epiisopiloturine has recently become the focus of study for various
medicinal properties, particularly for its anti-inflammatory and antischistosomal effect. The …

Ruthenium Complexes, an Emerging Class of Leishmanicidal Drug Candidates

SS Braga - Applied Biosciences, 2022 - mdpi.com
This review addresses the search for activity enhancement of leishmanicidal organic
compounds through their coordination chemistry with ruthenium. In an introduction to …

LAPONITE®-pilocarpine hybrid material: experimental and theoretical evaluation of pilocarpine conformation

VRR Cunha, FCDA Lima, VY Sakai, LMC Véras… - RSC …, 2017 - pubs.rsc.org
The intercalation of protonated pilocarpine (Pilo+) into model LAPONITE®(Lap) is here
investigated in order to address its conformational properties upon entrapment. Pilo is an …

Epiisopiloturine nanoencapsulation improve its oral bioavailability in the treatment of inflammatory bowel diseases

VPA de Almeida, TML da Silva, JJ da Silva Sousa… - Medical …, 2023 - Elsevier
Inflammatory bowel diseases (IBDs) are a group of diseases represented mainly by Crohn's
disease (CD) and ulcerative colitis (UC), whose current treatments are associated with a …