Sequence-specific DNA binding Pyrrole–imidazole polyamides and their applications
Y Kawamoto, T Bando, H Sugiyama - Bioorganic & medicinal chemistry, 2018 - Elsevier
Abstract Pyrrole–imidazole polyamides (Py–Im polyamides) are cell-permeable compounds
that bind to the minor groove of double-stranded DNA in a sequence-specific manner …
that bind to the minor groove of double-stranded DNA in a sequence-specific manner …
Nature-inspired design of smart biomaterials using the chemical biology of nucleic acids
In the natural cellular environment, nucleic acid biomolecules like DNA have biological
implications via structural modifications and through precise coordination with other …
implications via structural modifications and through precise coordination with other …
Ruthenium‐Catalyzed Hydroformylation of Alkenes by using Carbon Dioxide as the Carbon Monoxide Source in the Presence of Ionic Liquids
The reaction of [BMI⋅ Cl](BMI= 1‐butyl‐3‐methylimidazolium) or [BMMI⋅ Cl](BMMI= 3‐butyl‐
1, 2‐dimethylimidazolium) with Ru3 (CO) 12 generates Ru–hydride–carbonyl–carbene …
1, 2‐dimethylimidazolium) with Ru3 (CO) 12 generates Ru–hydride–carbonyl–carbene …
Therapeutic gene regulation using pyrrole–imidazole polyamides
Recent innovations in cutting-edge sequencing platforms have allowed the rapid
identification of genes associated with communicable, noncommunicable and rare diseases …
identification of genes associated with communicable, noncommunicable and rare diseases …
A synthetic DNA-binding inhibitor of SOX2 guides human induced pluripotent stem cells to differentiate into mesoderm
J Taniguchi, GN Pandian, T Hidaka… - Nucleic acids …, 2017 - academic.oup.com
Targeted differentiation of human induced pluripotent stem cells (hiPSCs) using only
chemicals would have value-added clinical potential in the regeneration of complex cell …
chemicals would have value-added clinical potential in the regeneration of complex cell …
Targeting 24 bp within telomere repeat sequences with tandem tetramer pyrrole–imidazole polyamide probes
Y Kawamoto, Y Kawamoto - Synthesis and Biological Evaluation of Pyrrole …, 2019 - Springer
Synthetic molecules that bind sequence-specifically to DNA have been developed for varied
biological applications, including anticancer activity, regulation of gene expression, and …
biological applications, including anticancer activity, regulation of gene expression, and …
Distinct DNA-based epigenetic switches trigger transcriptional activation of silent genes in human dermal fibroblasts
The influential role of the epigenome in orchestrating genome-wide transcriptional activation
instigates the demand for the artificial genetic switches with distinct DNA sequence …
instigates the demand for the artificial genetic switches with distinct DNA sequence …
Biomimetic artificial epigenetic code for targeted acetylation of histones
J Taniguchi, Y Feng, GN Pandian… - Journal of the …, 2018 - ACS Publications
While the central role of locus-specific acetylation of histone proteins in eukaryotic gene
expression is well established, the availability of designer tools to regulate acetylation at …
expression is well established, the availability of designer tools to regulate acetylation at …
Identification of a small molecule that turns ON the pluripotency gene circuitry in human fibroblasts
A nontransgenic approach to reprogram mouse somatic cells into induced pluripotent stem
cells using only small molecules got achieved to propose a potential clinical-friendly cellular …
cells using only small molecules got achieved to propose a potential clinical-friendly cellular …
A synthetic DNA‐binding domain guides distinct chromatin‐modifying small molecules to activate an identical gene network
Synthetic dual‐function ligands targeting specific DNA sequences and histone‐modifying
enzymes were applied to achieve regulatory control over multi‐gene networks in living cells …
enzymes were applied to achieve regulatory control over multi‐gene networks in living cells …