The surprising discovery that the diatomic gas nitric oxide (NO) is generated by mammalian
cells and serves to regulate a multitude of physiological processes has continued to …

Arginine (L-arginine), is an amino acid involved in a number of biological processes,
including the biosynthesis of proteins, host immune response, urea cycle, and nitric oxide …

There is a pressing need for allogeneic chimeric antigen receptor (CAR)-immune cell
therapies that are safe, effective and affordable. We conducted a phase 1/2 trial of cord …

The Global Burden of Disease Study identified cardiovascular risk factors as leading causes
of global deaths and life years lost. Endothelial dysfunction represents a pathomechanism …

Arginase, a binuclear manganese metalloenzyme in the urea, catalyzes the hydrolysis of L-
arginine to urea and L-ornithine. Both isoforms, arginase 1 and arginase 2 perform …

Nitric oxide (NO) from endothelial NO synthase importantly contributes to vascular
homeostasis. Reduced NO production or increased scavenging during disease conditions …

The primary role of red blood cells (RBCs) is to transport oxygen to the tissues and carbon
dioxide to the lungs. However, emerging evidence suggests an important role of the RBC …

During an ST-elevation myocardial infarction (STEMI), the myocardium undergoes a
prolonged period of ischaemia. Reperfusion therapy is essential to minimize cardiac injury …

Arginase is a ubiquitous enzyme in the urea cycle (UC) that hydrolyzes L‐arginine to urea
and L‐ornithine. Two mammalian arginase isoforms, arginase1 (ARG1) and arginase2 …

The fundamental physiology of circulating red blood cells (RBCs) and platelets involving
regulation of oxygen transport and hemostasis, respectively, are well-described in the …