[HTML][HTML] TGF-β signaling in health and disease
J Massagué, D Sheppard - Cell, 2023 - cell.com
The TGF-β regulatory system plays crucial roles in the preservation of organismal integrity.
TGF-β signaling controls metazoan embryo development, tissue homeostasis, and injury …
TGF-β signaling controls metazoan embryo development, tissue homeostasis, and injury …
The roles and regulatory mechanisms of TGF-β and BMP signaling in bone and cartilage development, homeostasis and disease
Transforming growth factor-βs (TGF-βs) and bone morphometric proteins (BMPs) belong to
the TGF-β superfamily and perform essential functions during osteoblast and chondrocyte …
the TGF-β superfamily and perform essential functions during osteoblast and chondrocyte …
2022 ACC/AHA guideline for the diagnosis and management of aortic disease: a report of the American Heart Association/American College of Cardiology Joint …
Writing Committee Members, EM Isselbacher… - Journal of the American …, 2022 - jacc.org
Abstract Aim The “2022 ACC/AHA Guideline for the Diagnosis and Management of Aortic
Disease” provides recommendations to guide clinicians in the diagnosis, genetic evaluation …
Disease” provides recommendations to guide clinicians in the diagnosis, genetic evaluation …
Osteoarthritis: toward a comprehensive understanding of pathological mechanism
Osteoarthritis (OA) is the most common degenerative joint disease and a major cause of
pain and disability in adult individuals. The etiology of OA includes joint injury, obesity …
pain and disability in adult individuals. The etiology of OA includes joint injury, obesity …
Genetics of thoracic and abdominal aortic diseases: aneurysms, dissections, and ruptures
Dissections or ruptures of aortic aneurysms remain a leading cause of death in the
developed world, with the majority of deaths being preventable if individuals at risk are …
developed world, with the majority of deaths being preventable if individuals at risk are …
[HTML][HTML] TGF-β and BMP signaling in osteoblast, skeletal development, and bone formation, homeostasis and disease
Transforming growth factor-beta (TGF-β) and bone morphogenic protein (BMP) signaling
has fundamental roles in both embryonic skeletal development and postnatal bone …
has fundamental roles in both embryonic skeletal development and postnatal bone …
TGF-β and the TGF-β family: context-dependent roles in cell and tissue physiology
M Morikawa, R Derynck… - Cold Spring Harbor …, 2016 - cshperspectives.cshlp.org
The transforming growth factor-β (TGF-β) is the prototype of the TGF-β family of growth and
differentiation factors, which is encoded by 33 genes in mammals and comprises homo-and …
differentiation factors, which is encoded by 33 genes in mammals and comprises homo-and …
Transforming growth factor-β in stem cells and tissue homeostasis
Abstract TGF-β 1–3 are unique multi-functional growth factors that are only expressed in
mammals, and mainly secreted and stored as a latent complex in the extracellular matrix …
mammals, and mainly secreted and stored as a latent complex in the extracellular matrix …
Evaluating the clinical validity of gene-disease associations: an evidence-based framework developed by the clinical genome resource
With advances in genomic sequencing technology, the number of reported gene-disease
relationships has rapidly expanded. However, the evidence supporting these claims varies …
relationships has rapidly expanded. However, the evidence supporting these claims varies …
TGFβ/BMP signaling pathway in cartilage homeostasis
NGM Thielen, PM van der Kraan, APM van Caam - Cells, 2019 - mdpi.com
Cartilage homeostasis is governed by articular chondrocytes via their ability to modulate
extracellular matrix production and degradation. In turn, chondrocyte activity is regulated by …
extracellular matrix production and degradation. In turn, chondrocyte activity is regulated by …