All cells possess an internal stress response to cope with environmental and
pathophysiological challenges. Upon stress, cells reprogram their molecular functions to …

Cytoplasmic RNA structures such as stress granules (SGs) and processing bodies (PBs) are
functional byproducts of mRNA metabolism, sharing substrate mRNA, dynamic properties …

The most abundant mRNA post-transcriptional modification is N 6-methyladenosine (m6A),
which has broad roles in RNA biology,,,,. In mammalian cells, the asymmetric distribution of …

Some circular RNAs (circRNAs) were found to be translated through IRES-driven
mechanism, however the scope and functions of circRNA translation are unclear because …

The scanning model for eukaryotic mRNA translation initiation states that the small
ribosomal subunit, along with initiation factors, binds at the cap structure at the 5′ end of …

The cell has many ways to regulate the production of proteins. One mechanism is through
the changes to the machinery of translation initiation. These alterations favor the translation …

Rapid expression of the survival gene, inducible heat shock protein 70 (hsp70), is critical for
mounting cytoprotection against severe cellular stress, like elevated temperature. Hsp70 …

Recent work has brought to light many different mechanisms of translation initiation that
function in cells in parallel to canonical cap‐dependent initiation. This has important …

During carcinogenesis, almost all the biological processes are modified in one way or
another. Among these biological processes affected, anomalies in protein synthesis are …

The type II arginine methyltransferase PRMT5 is responsible for the symmetric dimethylation
of histone to generate the H3R8me2s and H4R3me2s marks, which correlate with the …