Despite the increasing use and success of interventional coronary reperfusion strategies,
morbidity and mortality from acute myocardial infarction are still substantial. Myocardial …

Reperfusion is mandatory to salvage ischemic myocardium from infarction, but reperfusion
per se contributes to injury and ultimate infarct size. Therefore, cardioprotection beyond that …

Background For several decades, intermediate metabolism and signal transduction have
been considered two independent entities. On one side stood the catabolic and anabolic …

Ischemic heart disease (IHD) remains the leading cause of death and disability worldwide.
For patients presenting with an acute myocardial infarction, the most effective treatment for …

The mitochondrial permeability transition pore was originally described in the 1970's as a
Ca 2+ activated pore and has since been attributed to the pathogenesis of many diseases …

Impaired estrogen receptor α (ERα) action promotes obesity and metabolic dysfunction in
humans and mice; however, the mechanisms underlying these phenotypes remain …

Ischaemic postconditioning (brief periods of ischaemia alternating with brief periods of
reflow applied at the onset of reperfusion following sustained ischaemia) effectively reduces …

Like Dr. Jeckyll and Mr. Hyde, mitochondria possess two distinct persona. Under normal
physiological conditions they synthesise ATP to meet the energy needs of the beating heart …

In addition to their normal physiological role in ATP production and metabolism,
mitochondria exhibit a dark side mediated by the opening of a non-specific pore in the inner …

Despite advances in cardioprotection, new therapeutic strategies capable of preventing
ischemia-reperfusion injury of patients are still needed. Here, we discover that sarcoplasmic …