Hepigenetics: a review of epigenetic modulators and potential therapies in hepatocellular carcinoma

MH Yousef, HAN El-Fawal… - BioMed Research …, 2020 - Wiley Online Library
Hepatocellular carcinoma is the fifth most common cancer worldwide and the second most
lethal, following lung cancer. Currently applied therapeutic practices rely on surgical …

Trichostatin A sensitizes hepatocellular carcinoma cells to enhanced NK cell-mediated killing by regulating immune-related genes

S Shin, M Kim, SJ Lee, KS Park… - Cancer genomics & …, 2017 - cgp.iiarjournals.org
Background/Aim: Hepatocellular carcinoma (HCC) is the second leading cause of cancer-
related death worldwide. The ability of HCC to avoid immune detection is considered one of …

HDAC1/2 inhibitor romidepsin suppresses DEN-induced hepatocellular carcinogenesis in mice

H Afaloniati, K Angelopoulou, A Giakoustidis… - OncoTargets and …, 2020 - Taylor & Francis
Background Hepatocellular carcinoma (HCC) is a frequently diagnosed cancer and a
leading cause of cancer-related death worldwide. Its rapid progression, combined with the …

[HTML][HTML] Genistein and trichostatin a induction of estrogen receptor alpha gene expression, apoptosis and cell growth inhibition in hepatocellular carcinoma HepG 2 …

M Sanaei, F Kavoosi, H Salehi - Asian Pacific journal of cancer …, 2017 - ncbi.nlm.nih.gov
Epigenetic changes such as DNA methylation and histone acetylation play important roles in
determining gene expression. Hypermethylation of CpG islands of the promoter region of …

Evaluation of Cocaine Effect on Endogenous Metabolites of HepG2 Cells Using Targeted Metabolomics

A Krokos, O Deda, C Virgiliou, H Gika, N Raikos… - Molecules, 2021 - mdpi.com
Cocaine toxicity has been a subject of study because cocaine is one of the most common
and potent drugs of abuse. In the current study the effect of cocaine on human liver cancer …

Activation of peroxisome proliferator-activated receptor gamma in mammary epithelial cells upregulates the expression of tumor suppressor Cyld to mediate growth …

A Pseftogas, C Gonidas, G Mosialos - The International Journal of …, 2017 - Elsevier
Several studies have implicated the downregulation of the tumor suppressor Cyld
expression in breast cancer development. However, the mechanisms that regulate Cyld …

Knockdown of microRNA-130b improves doxorubicin sensitivity in bladder urothelial carcinoma by negatively regulating cylindromatosis expression

B Li, H Zhang - Archives of Medical Science: AMS, 2019 - pmc.ncbi.nlm.nih.gov
Introduction Chemotherapeutic resistance reduces the sensitivity of bladder urothelial
carcinoma (BUC) to chemotherapeutic drugs and contributes a barrier leading to treatment …

Characterization of tumor suppressor CYLD expression in clear cell renal cell carcinoma

D Koutsoumparis, E Constantinou… - Journal of Biological …, 2022 - ejournals.lib.auth.gr
Cyld is a tumor suppressor gene that has attracted particular interest recently, due to its
involvement in many types of neo-plasia, including head and neck squamous cell …

The Function of the Tumor Suppressor CYLD in Endothelial-Associated and Epigenetic Processes in Malignant Melanoma

M Schott - 2022 - search.proquest.com
Die Deubiquitinase CYLD beeinflusst ein weites Spektrum an physiologischen Prozessen,
welche von der Immunreaktion und Entzündung bis hin zur Zell-Zyklus-Progression oder …

Epigenetic biomarkers in diagnosis, prognosis, and treatment of hepatocellular carcinoma

E Kvaratskhelia, K Kankava, S Surmava… - … and Precision Medicine …, 2022 - Elsevier
Hepatocellular carcinoma (HCC) is one of the most commonly occurring solid cancers
worldwide and is the second cause of death due to malignancy. Infection by hepatitis B and …