Role of gut microbiota in infectious and inflammatory diseases

MF Maciel-Fiuza, GC Muller, DMS Campos… - Frontiers in …, 2023 - frontiersin.org
Thousands of microorganisms compose the human gut microbiota, fighting pathogens in
infectious diseases and inhibiting or inducing inflammation in different immunological …

Mechanisms of viral mutation

R Sanjuán, P Domingo-Calap - Cellular and molecular life sciences, 2016 - Springer
The remarkable capacity of some viruses to adapt to new hosts and environments is highly
dependent on their ability to generate de novo diversity in a short period of time. Rates of …

The commensal microbiota and viral infection: a comprehensive review

N Li, WT Ma, M Pang, QL Fan, JL Hua - Frontiers in Immunology, 2019 - frontiersin.org
The human body is inhabited by a diverse microbial community that is collectively coined as
commensal microbiota. Recent research has greatly advanced our understanding of how …

Extreme heterogeneity of influenza virus infection in single cells

AB Russell, C Trapnell, JD Bloom - Elife, 2018 - elifesciences.org
Viral infection can dramatically alter a cell's transcriptome. However, these changes have
mostly been studied by bulk measurements on many cells. Here we use single-cell mRNA …

Choosing a cellular model to study SARS-CoV-2

GA Pires De Souza, M Le Bideau, C Boschi… - Frontiers in cellular …, 2022 - frontiersin.org
As new pathogens emerge, new challenges must be faced. This is no different in infectious
disease research, where identifying the best tools available in laboratories to conduct an …

Microbiome analysis for wastewater surveillance during COVID-19

KD Brumfield, M Leddy, M Usmani, JA Cotruvo… - MBio, 2022 - journals.asm.org
Wastewater surveillance (WS), when coupled with advanced molecular techniques, offers
near real-time monitoring of community-wide transmission of SARS-CoV-2 and allows …

Bacteria facilitate enteric virus co-infection of mammalian cells and promote genetic recombination

AK Erickson, PR Jesudhasan, MJ Mayer, A Narbad… - Cell host & …, 2018 - cell.com
RNA viruses exist in genetically diverse populations due to high levels of mutations, many of
which reduce viral fitness. Interestingly, intestinal bacteria can promote infection of several …

HSV-1 single-cell analysis reveals the activation of anti-viral and developmental programs in distinct sub-populations

N Drayman, P Patel, L Vistain, S Tay - Elife, 2019 - elifesciences.org
Viral infection is usually studied at the population level by averaging over millions of cells.
However, infection at the single-cell level is highly heterogeneous, with most infected cells …

SARS-CoV-2 infection triggers pro-atherogenic inflammatory responses in human coronary vessels

N Eberhardt, MG Noval, R Kaur, L Amadori… - Nature cardiovascular …, 2023 - nature.com
Patients with coronavirus disease 2019 (COVID-19) present increased risk for ischemic
cardiovascular complications up to 1 year after infection. Although the systemic inflammatory …

Quantifying influenza virus diversity and transmission in humans

LLM Poon, T Song, R Rosenfeld, X Lin, MB Rogers… - Nature …, 2016 - nature.com
Influenza A virus is characterized by high genetic diversity,,. However, most of what is known
about influenza evolution has come from consensus sequences sampled at the …