The metabolic charts memorized in early biochemistry courses, and then later forgotten,
have come back to haunt many immunologists with new recognition of the importance of …

Epithelial-to-mesenchymal transition (EMT) is a conserved cellular process critical for
embryogenesis, wound healing, and cancer metastasis. During EMT, cells undergo large …

Amino acids not only play a vital role in the synthesis of biological molecules such as
proteins in cancer malignant cells, they are also essential metabolites for immune cell …

Several metabolites serve as substrates for histone modifications and communicate
changes in the metabolic environment to the epigenome. Technologies such as …

Background Glioblastoma is the most frequent and high-grade adult malignant central
nervous system tumor. The prognosis is still poor despite the use of combined therapy …

Extensive metabolic heterogeneity in breast cancers has limited the deployment of
metabolic therapies. To enable patient stratification, we studied the metabolic landscape in …

Background Oral squamous cell carcinoma (OSCC) has increased in incidence from 1990 to
2017, especially in South and Southeast Asia. It is often diagnosed at an advanced stage …

Enzymes have evolved to catalyze their precise reactions at the necessary rates, locations,
and time to facilitate our development, to respond to a variety of insults and challenges, and …

The biological challenges facing humanity are complex, multi-factorial, and are intimately
tied to the future of our health, welfare, and stewardship of the Earth. Tackling problems in …

Epithelial-to-mesenchymal transition (EMT) is a developmentally conserved cellular process
critical for tumor metastasis. EMT enables malignant epithelial cells to acquire mesenchymal …