The SLC30 family of zinc transporters–a review of current understanding of their biological and pathophysiological roles
L Huang, S Tepaamorndech - Molecular aspects of medicine, 2013 - Elsevier
Two families of zinc (Zn2+) transporters are involved in zinc homeostasis in the body, SLC30
(ZnT, zinc transporter) and SLC39 (ZIP, Zinc (Zn2+)–Iron (Fe2+) Permease). The two zinc …
(ZnT, zinc transporter) and SLC39 (ZIP, Zinc (Zn2+)–Iron (Fe2+) Permease). The two zinc …
Current understanding of ZIP and ZnT zinc transporters in human health and diseases
T Kambe, A Hashimoto, S Fujimoto - Cellular and molecular life sciences, 2014 - Springer
Abstract Zinc transporters, the Zrt-, Irt-like protein (ZIP) family and the Zn transporter (ZnT)
family transporters, are found in all aspects of life. Increasing evidence has clarified the …
family transporters, are found in all aspects of life. Increasing evidence has clarified the …
[HTML][HTML] Zinc in specialized secretory tissues: roles in the pancreas, prostate, and mammary gland
SL Kelleher, NH McCormick, V Velasquez, V Lopez - Advances in nutrition, 2011 - Elsevier
Zinc (Zn) is an essential micronutrient required for over 300 different cellular processes,
including DNA and protein synthesis, enzyme activity, and intracellular signaling. Cellular Zn …
including DNA and protein synthesis, enzyme activity, and intracellular signaling. Cellular Zn …
Zinc and infant nutrition
ML Ackland, AA Michalczyk - Archives of biochemistry and biophysics, 2016 - Elsevier
Zinc is essential for a wide variety of cellular processes in all cells. It is a critical dietary
nutrient, particularly in the early stages of life. In the early neonatal period, adequate sources …
nutrient, particularly in the early stages of life. In the early neonatal period, adequate sources …
ROS and intracellular ion channels
Oxidative stress is a well-known driver of numerous pathological processes involving protein
and lipid peroxidation and DNA damage. The resulting increase of pro-apoptotic pressure …
and lipid peroxidation and DNA damage. The resulting increase of pro-apoptotic pressure …
Functional analysis of SLC39A8 mutations and their implications for manganese deficiency and mitochondrial disorders
Abstract SLC39A8 encodes ZIP8, a divalent metal ion transporter. Mutations in the SLC39A8
gene are associated with congenital disorder of glycosylation type II and Leigh syndrome …
gene are associated with congenital disorder of glycosylation type II and Leigh syndrome …
Genetic and physiological factors affecting human milk production and composition
Human milk is considered the optimal nutrition for infants as it provides additional attributes
other than nutritional support for the infant and contributes to the mother's health as well …
other than nutritional support for the infant and contributes to the mother's health as well …
Compound Heterozygous Mutations in SLC30A2/ZnT2 Results in Low Milk Zinc Concentrations: A Novel Mechanism for Zinc Deficiency in a Breast-Fed Infant
N Itsumura, Y Inamo, F Okazaki, F Teranishi, H Narita… - PloS one, 2013 - journals.plos.org
Zinc concentrations in breast milk are considerably higher than those of the maternal serum,
to meet the infant's requirements for normal growth and development. Thus, effective …
to meet the infant's requirements for normal growth and development. Thus, effective …
Zinc deficiency and its management in the pediatric population: a literature review and proposed etiologic classification
MD Corbo, J Lam - Journal of the American Academy of Dermatology, 2013 - Elsevier
Zinc is a trace element essential to the gastrointestinal, immune, integumentary,
reproductive, and central nervous systems. Zinc deficiency is prevalent in many areas of the …
reproductive, and central nervous systems. Zinc deficiency is prevalent in many areas of the …
Molecular architecture and function of ZnT transporters
T Kambe - Current topics in membranes, 2012 - Elsevier
Zinc transporters (ZnT) form an important class of zinc efflux proteins in mammals. Nine ZnT
transporters, designated ZnT1–ZnT8 and ZnT10, have been identified to date. Recent …
transporters, designated ZnT1–ZnT8 and ZnT10, have been identified to date. Recent …